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However, the ability of <jats:sup>18<\/jats:sup>F\u2010florzolotau PET imaging to topographically characterize tau pathology in corticobasal syndrome (CBS) remains unclear. Further, the question as to whether disease\u2010level differences exist with other neurodegenerative tauopathies is still unanswered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the topographical patterns of tau pathology in the living brains of patients with CBS using <jats:sup>18<\/jats:sup>F\u2010florzolotau PET imaging and to examine whether differences with other tauopathies exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010florzolotau PET imaging was performed in 20 consecutive patients with CBS, 20 cognitively healthy controls (HCs), 20 patients with Alzheimer's disease (AD), and 16 patients with progressive supranuclear palsy\u2013Richardson's syndrome (PSP\u2010RS). Cerebrospinal fluid (CSF) levels of \u03b2\u2010amyloid biomarkers were quantified in all patients with CBS. <jats:sup>18<\/jats:sup>F\u2010florzolotau uptake was quantitatively assessed using standardized uptake value ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 20 patients with CBS, 19 (95%) were negative for CSF biomarkers of amyloid pathology; of them, three had negative <jats:sup>18<\/jats:sup>F\u2010florzolotau PET findings. Compared with HCs, patients with CBS showed increased <jats:sup>18<\/jats:sup>F\u2010florzolotau signals in both cortical and subcortical regions. In addition, patients with CBS were characterized by higher tracer retentions in subcortical regions compared with those with AD and showed a trend toward higher signals in cortical areas compared with PSP\u2010RS. An asymmetric pattern of <jats:sup>18<\/jats:sup>F\u2010florzolotau uptake was associated with an asymmetry of motor severity in patients with CBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In vivo <jats:sup>18<\/jats:sup>F\u2010florzolotau PET imaging holds promise for distinguishing CBS in the spectrum of neurodegenerative tauopathies. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29338","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T23:25:24Z","timestamp":1675812324000},"page":"579-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<scp><sup>18<\/sup>F\u2010Florzolotau<\/scp> Positron Emission Tomography Imaging of Tau Pathology in the Living Brains of Patients with Corticobasal Syndrome"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng\u2010Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-0042","authenticated-orcid":false,"given":"Jia\u2010Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center, National Center for Neurological Disorders, and National Clinical Research Center for Aging and Medicine, Huashan Hospital Fudan University  Shanghai 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