{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:09:23Z","timestamp":1790122163333,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071201"],"award-info":[{"award-number":["82071201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071997"],"award-info":[{"award-number":["82071997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Development of disease\u2010modifying therapeutic trials of progressive supranuclear palsy (PSP) urges the need for sensitive fluid biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to explore the utility of plasma biomarkers in the diagnosis, differential diagnosis, and assessment of disease severity, brain atrophy, and tau deposition in PSP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma biomarkers were measured using a single\u2010molecule array in a cohort composed of patients with PSP, Parkinson's disease (PD), multiple system atrophy with predominant parkinsonism (MSA\u2010P), and healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma neurofilament light chain (NfL) outperformed other plasma makers (ie, glial fibrillary acidic protein [GFAP], phosphorylated\u2010tau 181 [p\u2010tau181], amyloid\u2010\u03b2 1\u201340, amyloid\u2010\u03b2 1\u201342) in identifying PSP from HC (area under the curve [AUC]\u00a0=\u00a00.904) and from MSA\u2010P (AUC\u00a0=\u00a00.711). Plasma GFAP aided in distinguishing PSP from HC (AUC\u00a0=\u00a00.774) and from MSA\u2010P (AUC\u00a0=\u00a00.832). It correlated with brainstem atrophy and higher regional tau accumulation. However, plasma p\u2010tau181 neither helped in diagnosis nor was it associated with clinical or neuroimaging measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma NfL and GFAP showed different values in differentiating PSP from HC or controls with other forms of neurodegenerative parkinsonism and detecting disease severity, brain atrophy, or tau deposition in PSP. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29339","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T23:05:31Z","timestamp":1676329531000},"page":"676-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Plasma Biomarkers and Positron Emission Tomography Tau Pathology in Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-6025","authenticated-orcid":false,"given":"Shu\u2010Yi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College Fudan University, National Center for Neurological Disorders  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College Fudan University, National Center for Neurological Disorders  Shanghai 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National Center for Neurological Disorders  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College Fudan University, National Center for Neurological Disorders  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College Fudan University, National Center for Neurological Disorders  Shanghai 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