{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:48:30Z","timestamp":1784908110939,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side\u2010effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13\u201330\u2009Hz). We hypothesize that this pattern is symptom\u2010specific, thus accompanying DBS\u2010induced slowness in dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 6 dystonia patients, pallidal rest recordings with a sensing\u2010enabled DBS device were performed and tapping speed was assessed using marker\u2010less pose estimation over 5 time points following cessation of DBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After cessation of pallidal stimulation, movement speed increased over time (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). A linear mixed\u2010effects model revealed that pallidal beta activity explained 77% of the variance in movement speed across patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between beta oscillations and slowness across disease entities provides further evidence for symptom\u2010specific oscillatory patterns in the motor circuit. Our findings might help DBS therapy improvements, as DBS\u2010devices able to adapt to beta oscillations are already commercially available. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29347","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T06:55:07Z","timestamp":1676876107000},"page":"894-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Pallidal Beta Activity Is Linked to Stimulation\u2010Induced Slowness in Dystonia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-8250","authenticated-orcid":false,"given":"Roxanne","family":"Lofredi","sequence":"first","affiliation":[{"name":"Department of Neurology, Movement Disorders and Neuromodulation Unit Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-2470","authenticated-orcid":false,"given":"Ute","family":"Scheller","sequence":"additional","affiliation":[{"name":"Department of Neurology, Movement Disorders and Neuromodulation Unit Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology Georg\u2010August\u2010Universit\u00e4t G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurika","family":"Mindermann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Movement Disorders and Neuromodulation Unit Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin 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