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Generalized synaptic degeneration may be one key contributor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to investigate whether local cortical synaptic loss is proportionally linked to the magnitude of hypometabolism in Lewy body disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Using in vivo positron emission tomography (PET) we investigated cerebral glucose metabolism and quantified the density of cerebral synapses, as measured with [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose ([\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG) PET and [\n                      <jats:sup>11<\/jats:sup>\n                      C]UCB\u2010J, respectively. Volumes\u2010of\u2010interest were defined on magnetic resonance T1 scans and regional standard uptake value ratios\u20101 values were obtained for 14 pre\u2010selected brain regions. Between\u2010group comparisons were conducted at voxel\u2010level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed regional differences in both synaptic density and cerebral glucose consumption in our cohorts of non\u2010demented and demented patients with Parkinson's disease or dementia with Lewy bodies compared to healthy subjects. Additionally, voxel\u2010wise comparisons showed a clear difference in cortical regions between demented patients and controls for both tracers. Importantly, our findings strongly suggested that the magnitude of reduced glucose uptake exceeded the magnitude of reduced cortical synaptic density.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Here, we investigated the relationship between in vivo glucose uptake and the magnitude of synaptic density as measured using [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET and [\n                      <jats:sup>11<\/jats:sup>\n                      C]UCB\u2010J PET in Lewy body patients. The magnitude of reduced [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG uptake was greater than the corresponding decline in [\n                      <jats:sup>11<\/jats:sup>\n                      C]UCB\u2010J binding. Therefore, the progressive hypometabolism seen in Lewy body disorders cannot be fully explained by generalized synaptic degeneration. \u00a9 2023 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29375","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T03:49:25Z","timestamp":1678506565000},"page":"796-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Synaptic Density and Glucose Consumption in Patients with\n                    <scp>Lewy Body Diseases<\/scp>\n                    : An [\n                    <scp>\n                      <sup>11<\/sup>\n                      C\n                    <\/scp>\n                    ]\n                    <scp>UCB\u2010J<\/scp>\n                    and [\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>FDG PET<\/scp>\n                    Study"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-2170","authenticated-orcid":false,"given":"Katrine B.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and PET Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Christina","family":"Schacht","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Aarhus University Hospital  Aarhus 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