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Whether parkinsonian syndromes are distinguishable based on neuronal oscillations has not been investigated so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to identify spectral properties specific to atypical parkinsonism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured resting\u2010state magnetoencephalography in 14 patients with corticobasal syndrome (CBS), 16 patients with progressive supranuclear palsy (PSP), 33 patients with idiopathic Parkinson's disease, and 24 healthy controls. We compared spectral power as well as amplitude and frequency of power peaks between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Atypical parkinsonism was associated with spectral slowing, distinguishing both CBS and PSP from Parkinson's disease (PD) and age\u2010matched healthy controls. Patients with atypical parkinsonism showed a shift in \u03b2 peaks (13\u201330\u2009Hz) toward lower frequencies in frontal areas bilaterally. A concomitant increase in \u03b8\/\u03b1 power relative to controls was observed in both APS and PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spectral slowing occurs in atypical parkinsonism, affecting frontal \u03b2 oscillations in particular. Spectral slowing with a different topography has previously been observed in other neurodegenerative disorders, such as Alzheimer's disease, suggesting that spectral slowing might be an electrophysiological marker of neurodegeneration. As such, it might support differential diagnosis of parkinsonian syndromes in the future. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29378","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T03:29:50Z","timestamp":1684553390000},"page":"806-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Slowing of Frontal <scp>\u03b2<\/scp> Oscillations in Atypical Parkinsonism"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-5868","authenticated-orcid":false,"given":"Marius","family":"Kr\u00f6sche","sequence":"first","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich Heine University  D\u00fcsseldorf 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