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There is a need to understand the mechanisms by which cerebrovascular dysfunction is altered in participants with PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study is to test the hypothesis that participants with PD exhibit a significant reduction in the ability of the cerebral vessels to dilate in response to vasoactive challenges relative to healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study uses a vasodilatory challenge while participants undergo functional magnetic resonance imaging to quantify the amplitude and delay of cerebrovascular reactivity in participants with PD relative to age and sex\u2010matched HC. An analysis of covariance was used to evaluate differences in cerebrovascular reactivity amplitude and latency between PD participants and HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant main effect of group was observed for whole\u2010brain cerebrovascular reactivity amplitude (<jats:italic>F<\/jats:italic><jats:sub>(1, 28)<\/jats:sub>\u2009=\u20094.38, <jats:italic>p<\/jats:italic>\u2009=\u20090.046, Hedge's <jats:italic>g\u2009=<\/jats:italic>\u20090.73) and latency (<jats:italic>F<\/jats:italic><jats:sub>(1, 28)<\/jats:sub>\u2009=\u200916.35, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Hedge's <jats:italic>g<\/jats:italic>\u2009=\u20091.42). Participants with PD exhibited reduced whole\u2010brain amplitude and increased latencies in cerebrovascular reactivity relative to HC. The evaluation of regional effects indicates that the largest effects were observed in the cuneus, precuneus, and parietal regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PD participants exhibited reduced and delayed cerebrovascular reactivity. This dysfunction may play an important role in chronic hypoxia, neuroinflammation, and protein aggregation, mechanisms that could lead to disease progression. Cerebrovascular reactivity may serve as an important biomarker and target for future interventions. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29429","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T23:13:45Z","timestamp":1683587625000},"page":"1262-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-3391","authenticated-orcid":false,"given":"Sephira G.","family":"Ryman","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience The Mind Research Network  Albuquerque New Mexico USA"},{"name":"Nene and Jamie 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Erhardt","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of New Mexico  Albuquerque New Mexico USA"},{"name":"Neurology|Medicine New Mexico VA Health Care System  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Vakhtin","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience The Mind Research Network  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-7143","authenticated-orcid":false,"given":"Kathleen 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