{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:01:35Z","timestamp":1792083695654,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2698"],"award-info":[{"award-number":["FOR 2698"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor processes, essential for the control of goal\u2010directed behavior, is altered in patients with FMD is less clear. A detailed investigation of these processes is crucial to foster a better understanding of the pathophysiology of FMD and can systematically be achieved in the framework of the theory of event coding (TEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to investigate perception\u2013action integration processes on a behavioral and neurophysiological level in patients with FMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 21 patients and 21 controls were investigated with a TEC\u2010related task, including concomitant electroencephalogram (EEG) recording. We focused on EEG correlates established to reflect perception\u2013action integration processes. Temporal decomposition allowed to distinguish between EEG codes reflecting sensory (S\u2010cluster), motor (R\u2010cluster), and integrated sensory\u2013motor processing (C\u2010cluster). We also applied source localization analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Behaviorally, patients revealed stronger binding between perception and action, as evidenced by difficulties in reconfiguring previously established stimulus\u2013response associations. Such hyperbinding was paralleled by a modulation of neuronal activity clusters, including reduced C\u2010cluster modulations of the inferior parietal cortex and altered R\u2010cluster modulations in the inferior frontal gyrus. Correlations of these modulations with symptom severity were also evident.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that FMD is characterized by altered integration of sensory information with motor processes. Relations between clinical severity and both behavioral performance and neurophysiological abnormalities indicate that perception\u2013action integration processes are central and a promising concept for the understanding of FMD. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29458","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T14:04:57Z","timestamp":1686751497000},"page":"1399-1409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Perception\u2013Action Integration Is Altered in Functional Movement Disorders"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3569-6242","authenticated-orcid":false,"given":"Anne","family":"Weissbach","sequence":"first","affiliation":[{"name":"Institute of Systems Motor Science, Center of Brain, Behavior, and Metabolism (CBBM) University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Moy\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Systems Motor Science, Center of Brain, Behavior, and Metabolism (CBBM) University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Takacs","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine TU Dresden  Dresden 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Center of Brain, Behavior, and Metabolism (CBBM) University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Neurology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-6376","authenticated-orcid":false,"given":"Simone","family":"Zittel","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Institute of Systems Motor Science, Center of Brain, Behavior, and Metabolism (CBBM) University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frings","sequence":"additional","affiliation":[{"name":"Department of Cognitive Psychology Trier University Trier  Trier 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