{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:20:31Z","timestamp":1792725631965,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["RED 00314\u201016"],"award-info":[{"award-number":["RED 00314\u201016"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["18298"],"award-info":[{"award-number":["18298"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["Programa Nacional de Gen\u00f4mica e Sa\u00fade de Precis"],"award-info":[{"award-number":["Programa Nacional de Gen\u00f4mica e Sa\u00fade de Precis"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","award":["2020\u20103"],"award-info":[{"award-number":["2020\u20103"]}],"id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex differences in Parkinson's disease (PD) risk are well\u2010known. However, the role of sex chromosomes in the development and progression of PD is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to perform the first X\u2010chromosome\u2013wide association study for PD risk in a Latin American cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from three admixed cohorts: (1) Latin American Research consortium on the Genetics of Parkinson's Disease (n\u2009=\u20091504) as discover cohort, and (2) Latino cohort from International Parkinson Disease Genomics Consortium (n\u2009=\u2009155) and (3) Bambui Aging cohort (n\u2009=\u20091442) as replication cohorts. We also developed an X\u2010chromosome framework specifically designed for admixed populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified eight linkage disequilibrium regions associated with PD. We replicated one of these regions (top variant rs525496; discovery odds ratio [95% confidence interval]: 0.60 [0.478\u20130.77], <jats:italic>P<\/jats:italic>\u2009=\u20093.13\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup> replication odds ratio: 0.60 [0.37\u20130.98], <jats:italic>P<\/jats:italic>\u2009=\u20090.04). rs5525496 is associated with multiple expression quantitative trait loci in brain and non\u2010brain tissues, including <jats:italic>RAB9B<\/jats:italic>, <jats:italic>H2BFM<\/jats:italic>, <jats:italic>TSMB15B<\/jats:italic>, and <jats:italic>GLRA4<\/jats:italic>, but colocalization analysis suggests that rs5525496 may not mediate risk by expression of these genes. We also replicated a previous X\u2010chromosome\u2013wide association study finding (rs28602900), showing that this variant is associated with PD in non\u2010European populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results reinforce the importance of including X\u2010chromosome and diverse populations in genetic studies. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29508","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T03:05:31Z","timestamp":1689822331000},"page":"1625-1635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>X\u2010Chromosome<\/scp> Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-6452","authenticated-orcid":false,"given":"Thiago P.","family":"Leal","sequence":"first","affiliation":[{"name":"Lerner Research Institute, Genomic Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa C.","family":"Rao","sequence":"additional","affiliation":[{"name":"The Parkinson's Foundation  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"French\u2010Kwawu","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus H.","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Center for Research on Genomics and Global Health National Human Genome Research Institute, National Institutes of Health  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