{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:16:35Z","timestamp":1789517795692,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["Z01AG00053404"],"award-info":[{"award-number":["Z01AG00053404"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["Z01AG00095719"],"award-info":[{"award-number":["Z01AG00095719"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid\u2010\u03b2, phosphorylated tau (p\u2010tau), and total tau (t\u2010tau) in cerebrospinal fluid are established biomarkers for Alzheimer's disease (AD). In other neurodegenerative diseases, such as Parkinson's disease (PD), these biomarkers have also been found to be altered, and the molecular mechanisms responsible for these alterations are still under investigation. Moreover, the interplay between these mechanisms and the diverse underlying disease states remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate genetic contributions to the AD biomarkers and assess the commonality and heterogeneity of the associations per underlying disease status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted genome\u2010wide association studies (GWASs) for the AD biomarkers on subjects from the Parkinson's Progression Markers Initiative, the Fox Investigation for New Discovery of Biomarkers, and the Alzheimer's Disease Neuroimaging Initiative, and meta\u2010analyzed with the largest AD GWAS. We tested heterogeneity of associations of interest between different disease statuses (AD, PD, and control).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We observed three GWAS signals: the\n                      <jats:italic>APOE<\/jats:italic>\n                      locus for amyloid\u2010\u03b2, the 3q28 locus between\n                      <jats:italic>GEMC1<\/jats:italic>\n                      and\n                      <jats:italic>OSTN<\/jats:italic>\n                      for p\u2010tau and t\u2010tau, and the 7p22 locus (top hit: rs60871478, an intronic variant for\n                      <jats:italic>DNAAF5<\/jats:italic>\n                      , also known as\n                      <jats:italic>HEATR2<\/jats:italic>\n                      ) for p\u2010tau. The 7p22 locus is novel and colocalized with the brain\n                      <jats:italic>DNAAF5<\/jats:italic>\n                      expression. Although no heterogeneity from underlying disease status was observed for the earlier GWAS signals, some disease risk loci suggested disease\u2010specific associations with these biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study identified a novel association at the intronic region of\n                      <jats:italic>DNAAF5<\/jats:italic>\n                      associated with increased levels of p\u2010tau across all diseases. We also observed some disease\u2010specific genetic associations with these biomarkers. Published 2023. This article is a U.S. Government work and is in the public domain in the USA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29511","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T05:50:13Z","timestamp":1691128213000},"page":"1697-1705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genome\u2010Wide Meta\u2010Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Parkinson's Disease Cohorts"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-3841","authenticated-orcid":false,"given":"Michael","family":"Ta","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"},{"name":"Data Tecnica International  Washington District of Columbia USA"},{"name":"Center for Alzheimer's and Related Dementias, 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