{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:06:37Z","timestamp":1785794797492,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Deep brain stimulation (DBS) has been increasingly used in the management of dyskinetic cerebral palsy (DCP). Data on long\u2010term effects and the safety profile are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed the efficacy and safety of pallidal DBS in pediatric patients with DCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The STIM\u2010CP trial was a prospective, single\u2010arm, multicenter study in which patients from the parental trial agreed to be followed\u2010up for up to 36\u2009months. Assessments included motor and non\u2010motor domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 16 patients included initially, 14 (mean inclusion age 14\u2009years) were assessed. There was a significant change in the (blinded) ratings of the total Dyskinesia Impairment Scale at 36\u2009months. Twelve serious adverse events (possibly) related to treatment were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DBS significantly improved dyskinesia, but other outcome parameters did not change significantly. Investigations of larger homogeneous cohorts are needed to further ascertain the impact of DBS and guide treatment decisions in DCP. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29516","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T10:58:12Z","timestamp":1687777092000},"page":"1736-1742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010Term Follow\u2010Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-4432","authenticated-orcid":false,"given":"Anne","family":"Koy","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schiller","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Huebl","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 University Medicine Berlin  Berlin Germany"},{"name":"Department of Neurology Munich Municipal Hospital Bogenhausen  Munich 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Functional Neurosurgery University Medical Center, Faculty of Medicine, University of Freiburg  Freiburg Germany"},{"name":"Center for Deep Brain Stimulation University Medical Center  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-9064","authenticated-orcid":false,"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel","family":"Saryyeva","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Kidney, Liver and Metabolic Diseases Hannover Medical School  Hannover 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