{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:47:22Z","timestamp":1786974442518,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that predominantly impacts a Caucasian population, but few efforts have explored racial differences in presentation and progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to assess the presentation and progression of HD across race groups using the Enroll\u2010HD longitudinal observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied propensity score matching for cytosine\u2013adenine\u2013guanine age product score, and age, to identify White, Hispanic, Asian, and Black participants from the Enroll\u2010HD database. We compared clinical presentations at baseline, and progression over time, using White participants as a control cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Black participants were more severe at baseline across all clinical measures. No significant differences in progression were observed between race groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We consider the factors driving clinical differences at baseline for Black participants. Our data emphasize the necessary improvement in underrepresented minority recruitment for studies of rare diseases. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29536","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T03:02:39Z","timestamp":1691636559000},"page":"1945-1949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Racial Differences in the Presentation and Progression of Huntington's Disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-2523","authenticated-orcid":false,"given":"Danielle A.","family":"Buchanan","sequence":"first","affiliation":[{"name":"Division of Cognitive and Behavioral Neurology, Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-9835","authenticated-orcid":false,"given":"Amy E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Cognitive and Behavioral Neurology, Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-6933","authenticated-orcid":false,"given":"Elicia C.","family":"Osigwe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-3318","authenticated-orcid":false,"given":"Anna C.","family":"Pfalzer","sequence":"additional","affiliation":[{"name":"Division of Cognitive and Behavioral Neurology, Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-4761","authenticated-orcid":false,"given":"Leah G.","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-7450","authenticated-orcid":false,"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-4021","authenticated-orcid":false,"given":"Hakmook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-4902","authenticated-orcid":false,"given":"Daniel O.","family":"Claassen","sequence":"additional","affiliation":[{"name":"Division of Cognitive and Behavioral Neurology, Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200575"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516047113"},{"key":"e_1_2_9_4_1","unstructured":"Looking Beneath the Surface: Racial Bias in the Treatment and Management of Pain|Health Disparities|JAMA Network Open|JAMA Network; 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Enroll\u2010HD.org; Published December 17 2020. Accessed December 15 2021.https:\/\/enroll-hd.org\/enrollhd_documents\/2020-10-R1\/ENROLL-HD-DataDictionary-2020-10-R1.pdf."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.87.11.1773"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:36:43Z","timestamp":1760960203000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/mds.29536"],"URL":"https:\/\/doi.org\/10.1002\/mds.29536","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,10]]},"assertion":[{"value":"2023-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}