{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:27:29Z","timestamp":1790281649185,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["P50DC01990"],"award-info":[{"award-number":["P50DC01990"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC019353"],"award-info":[{"award-number":["R01DC019353"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Laryngeal dystonia (LD) is focal task\u2010specific dystonia, predominantly affecting speech but not whispering or emotional vocalizations. Prior neuroimaging studies identified brain regions forming a dystonic neural network and contributing to LD pathophysiology. However, the underlying temporal dynamics of these alterations and their contribution to the task\u2010specificity of LD remain largely unknown. The objective of the study was to identify the temporal\u2013spatial signature of altered cortical oscillations associated with LD pathophysiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used high\u2010density 128\u2010electrode electroencephalography (EEG) recordings during symptomatic speaking and two asymptomatic tasks, whispering and writing, in 24 LD patients and 22 healthy individuals to investigate the spectral dynamics, spatial localization, and interregional effective connectivity of aberrant cortical oscillations within the dystonic neural network, as well as their relationship with LD symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptomatic speaking in LD patients was characterized by significantly increased gamma synchronization in the middle\/superior frontal gyri, primary somatosensory cortex, and superior parietal lobule, establishing the altered prefrontal\u2010parietal loop. Hyperfunctional connectivity from the left middle frontal gyrus to the right superior parietal lobule was significantly correlated with the age of onset and the duration of LD symptoms. Asymptomatic whisper in LD patients had not no statistically significant changes in any frequency band, whereas asymptomatic writing was characterized by significantly decreased synchronization of beta\u2010band power localized in the right superior frontal gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Task\u2010specific oscillatory activity of prefrontal\u2010parietal circuitry is likely one of the underlying mechanisms of aberrant heteromodal integration of information processing and transfer within the neural network leading to dystonic motor output. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29557","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T06:31:22Z","timestamp":1690266682000},"page":"1925-1935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Temporal Signature of Task\u2010Specificity in Isolated Focal Laryngeal Dystonia"],"prefix":"10.1002","volume":"38","author":[{"given":"Stefan K.","family":"Ehrlich","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Harvard Medical School and Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Battistella","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Harvard Medical School and Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-0437","authenticated-orcid":false,"given":"Kristina","family":"Simonyan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Harvard Medical School and Massachusetts Eye and Ear  Boston Massachusetts USA"},{"name":"Department of Neurology\u2014Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27617"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009140"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011922"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2018.09.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21464"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23315"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.97"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27649"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007317"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw363"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.05.034"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.03.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac031"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.7.1357"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200004)47:4<456::AID-ANA8>3.0.CO;2-Q"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097561"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105444"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89947-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abbbd6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.050"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.027"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00165"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.03.045"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2005.06.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00533-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-9-45"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2010.01061.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009165117"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23050"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103302"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.01.032"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-4694(97)00022-2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429355509"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.048"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.032"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476572"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.624"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26381"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08002"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.06.16.448658"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2044"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00045"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.12.2301"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11225-9"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.962957"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80012-3"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1698"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7878473"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.10.016"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25822"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27984"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105223"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.889714"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.08.029"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq023"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25029"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062877"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21250"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13067"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.001"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23553"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.011"},{"key":"e_1_2_9_69_1","doi-asserted-by":"crossref","unstructured":"SimonyanK.Inferior parietal cortex as a hub of loss of inhibition and maladaptive plasticity (Abstract S39). Annual Meeting of the Americal Academy of Neurology; Boston MA USA April 22\u201328 2017.","DOI":"10.1212\/WNL.88.16_supplement.S39.002"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00188"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.1"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.4.571"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.10.019"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21762"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1867"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh031"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1650"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh715"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.12.034"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.09.003"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23675"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20700"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.01.017"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.07.032"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.12.006"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3860-11.2012"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:36:12Z","timestamp":1760960172000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":85,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/mds.29557"],"URL":"https:\/\/doi.org\/10.1002\/mds.29557","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,25]]},"assertion":[{"value":"2023-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}