{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:38:24Z","timestamp":1781624304223,"version":"3.54.5"},"reference-count":93,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, studies on positron emission tomography (PET) with <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP\u2010RS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate FDG\u2010PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non\u2010RS variants of PSP (vPSP), and 46 age\u2010matched healthy controls. Two state\u2010of\u2010the art methods for the interpretation of FDG\u2010PET were compared: visual analysis supported by voxel\u2010based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP\u2010related pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false\u2010negative cases was 10% in the PSP\u2010RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false\u2010negative cases was 0% in the PSP\u2010RS subsample and 15% in the vPSP subsample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Visual interpretation of FDG\u2010PET supported by voxel\u2010based testing provides good accuracy for the detection of PSP\u2010RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP\u2010RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false\u2010positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel\u2010based testing of FDG\u2010PET in suspected PSP. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29581","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:57:00Z","timestamp":1693540620000},"page":"1901-1913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Automatic covariance pattern analysis outperforms visual reading of <sup>18<\/sup>F\u2010fluorodeoxyglucose\u2010positron emission tomography (<scp>FDG\u2010PET)<\/scp> in variant progressive supranuclear 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