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Subsequent expression quantitative trait loci mapping in the human brain and enrichment analyses were also performed.<\/jats:p><\/jats:sec>Results<\/jats:title>MiXeR analysis identified genetic overlap between PD and various BSPs, including total cortical surface area, average cortical thickness, and specific brain volumetric structures. Further analysis using conditional false discovery rate (FDR) identified 21 novel PD risk loci on associations with BSPs at conditional FDR\u2009<\u20090.01, and the conjunctional FDR analysis demonstrated that PD shared several genomic loci with certain BSPs at conjunctional FDR\u2009<\u20090.05. Among the shared loci, 16 credible mapped genes showed high expression in the brain tissues and were primarily associated with immune function\u2013related biological processes.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We confirmed the polygenic overlap with mixed directions of allelic effects between PD and BSPs and identified multiple shared genomic loci and risk genes, which are likely related to immune\u2010related biological processes. These findings provide insight into the complex genetic architecture associated with PD. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29598","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:40:39Z","timestamp":1700764839000},"page":"2258-2268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Shared Genetic Architecture between Parkinson's Disease and Brain Structural Phenotypes"],"prefix":"10.1002","volume":"38","author":[{"given":"Dong\u2010rui","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang\u2010jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital 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