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However, the mechanism for this modulation remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a study involving 17 patients with cervical dystonia (CD), seven of whom had prominent CD and 10 with generalized dystonia (GD) along with CD. We investigated the effects of neck vibration, a form of proprioceptive modulation, on spontaneous single\u2010neuron responses and local field potentials (LFPs) recorded from the globus pallidum externus (GPe) and internus (GPi).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings demonstrated that neck vibration notably increased the regularity of neck\u2010sensitive GPi neurons in focal CD patients. Additionally, in patients with GD and CD, the vibration enhanced the firing regularity of non\u2010neck\u2010sensitive neurons. These effects on single\u2010unit activity were also mirrored in ensemble responses measured through LFPs. Notably, the LFP modulation was particularly pronounced in areas populated with burst neurons compared to pause or tonic cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results from our study emphasize the significance of burst neurons in the pathogenesis of dystonia and in the efficacy of proprioceptive modulation for its treatment. Moreover, we observed that the effects of vibration on focal CD were prominent in the \u03b1 band LFP, indicating modulation of pallido\u2010cerebellar connectivity. Moreover, the pallidal effects of vibration in GD with CD involved modulation of cerebro\u2010pallidal \u03b8 band connectivity. Our analysis provides insight into how vibration\u2010induced changes in pallidal activity are integrated into the downstream motor circuit. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29603","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:05:53Z","timestamp":1694585153000},"page":"2094-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Proprioceptive Modulation of Pallidal Physiology in Cervical Dystonia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-2578","authenticated-orcid":false,"given":"Alexey","family":"Sedov","sequence":"first","affiliation":[{"name":"N.N. 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