{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:19:31Z","timestamp":1768835971359,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003136","name":"Edmond J. Safra Philanthropic Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004089","name":"Krembil Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000241","name":"Physicians' Services Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012456","name":"Toronto General and Western Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Misfolded \u03b1\u2010synuclein in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) can be detected using the real\u2010time quaking\u2010induced conversion (RT\u2010QuIC) technique in cerebrospinal fluid (CSF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives are (1) to examine misfolded CSF \u03b1\u2010synuclein incidence, and (2) to compare clinical presentation, sports history, brain volumes, and RT\u2010QuIC \u03b1\u2010synuclein positivity in former athletes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty former athletes with magnetic resonance imaging, neuropsychological testing, and CSF analyzed for phosphorylated tau 181 (p\u2010tau), total tau (t\u2010tau), amyloid\u2010\u03b2 42 (A\u03b242), and neurofilament light chain (NfL). CSF \u03b1\u2010synuclein was detected using RT\u2010QuIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six (20%) former athletes were \u03b1\u2010synuclein positive. \u03b1\u2010Synuclein positive athletes were similar to \u03b1\u2010synuclein negative athletes on demographics, sports history, clinical features, CSF p\u2010tau, t\u2010tau, A\u03b242, and NfL; however, had lower grey matter volumes in the right inferior orbitofrontal, right anterior insula and right olfactory cortices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u03b1\u2010Synuclein RT\u2010QuIC analysis of CSF may be useful as a prodromal biofluid marker of PD and DLB. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29621","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T13:06:08Z","timestamp":1696424768000},"page":"2125-2131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Misfolded \u03b1\u2010Synuclein in Cerebrospinal Fluid of Contact Sport Athletes"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-9620","authenticated-orcid":false,"given":"Anna","family":"Vasilevskaya","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Division of Neurology Toronto Western Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-6321","authenticated-orcid":false,"given":"Ivan","family":"Martinez\u2010Valbuena","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Anastassiadis","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Division of Neurology Toronto Western Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foad","family":"Taghdiri","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"},{"name":"Division of Neurology Toronto Western Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mozhgan","family":"Khodadadi","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apameh","family":"Tarazi","sequence":"additional","affiliation":[{"name":"Division of Neurology Toronto Western Hospital, University Health Network  Toronto Ontario Canada"},{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Green","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"},{"name":"KITE Research Institute, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Colella","sequence":"additional","affiliation":[{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"},{"name":"KITE Research Institute, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Wennberg","sequence":"additional","affiliation":[{"name":"Division of Neurology Toronto Western Hospital, University Health Network  Toronto Ontario Canada"},{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mikulis","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neuroradiology, Joint Department of Medical Imaging University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Deborah","family":"Davis","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"Division of Brain, Imaging, and Behaviour; Krembil Brain Institute University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-5511","authenticated-orcid":false,"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program and Krembil Brain Institute University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Tator","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurosurgery Toronto Western Hospital, Krembil Brain Institute, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-8497","authenticated-orcid":false,"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Division of Neurology Toronto Western Hospital, University Health Network  Toronto Ontario Canada"},{"name":"Canadian Concussion Centre Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly065"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/fmch-2020-000390"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1948"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908483"},{"issue":"2","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1212\/CON.0000000000000309","article-title":"Lewy body dementias: dementia with Lewy bodies and Parkinson disease dementia","volume":"22","author":"Gomperts SN","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51280"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.338"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02160-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30449-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00232-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101444"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25458"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02206-x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0306-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a2cbd1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007231"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09363-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14251"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-021-01693-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00805-8"},{"key":"e_1_2_8_23_1","first-page":"405","volume-title":"International Review of Neurobiology","author":"De Micco R","year":"2018"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9135-x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25829"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:51:38Z","timestamp":1760957498000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,4]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/mds.29621"],"URL":"https:\/\/doi.org\/10.1002\/mds.29621","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,4]]},"assertion":[{"value":"2023-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}