{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:46:55Z","timestamp":1785466015504,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A2C4001834"],"award-info":[{"award-number":["2022R1A2C4001834"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evaluating eye movements in Parkinson's disease (PD) provides valuable insights into the underlying pathophysiological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to investigate the relationship between monoaminergic degeneration and ocular motor abnormalities in de novo PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Drug\u2010naive PD patients who underwent <jats:italic>N<\/jats:italic>\u2010(3\u2010[<jats:sup>18<\/jats:sup>F]fluoropropyl)\u20102\u2010carbomethoxy\u20103\u2010(4\u2010iodophenyl) nortropane positron emission tomography scans and video\u2010oculography at diagnosis were eligible. Measurements of saccadic accuracy, latency, and smooth pursuit gain and square wave jerk frequency were collected. Patients underwent Movement Disorders Society\u2013Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) and detailed cognitive tests. We investigated the associations between ocular motor measurements and specific tracer uptake ratios (SUR) in the caudate nucleus, anterior and posterior putamen, thalamus, and dorsal raphe nuclei, along with motor and cognitive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred twenty\u2010four subjects were included in this study. Saccadic accuracy was positively associated with parkinsonian motor severity expressed as Hoehn and Yahr stages, MDS\u2010UPDRS Part III scores, and subscores for bradykinesia and rigidity but not with tremor scores (<jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009&lt;\u20090.05). Saccadic accuracy correlated with poor performances in the Rey\u2010Complex\u2010Figure copy, and latency with the Digit Symbol Coding and the Montreal Cognitive Assessment scores (<jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009&lt;\u20090.05). Prolonged saccadic latency correlated with reduced thalamic SUR, whereas decreased saccadic accuracy correlated with reduced SUR in the anterior and posterior putamen (<jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009&lt;\u20090.05). Reduced smooth pursuit gain showed associations with reduced SUR in the dorsal raphe, a serotonin\u2010predominant region, but did not correlate with parkinsonism severity scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Defective dopaminergic and nondopaminergic neural systems may discretely influence ocular motor function in de novo PD patients. \u00a9 2023 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29623","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:58:52Z","timestamp":1697529532000},"page":"2291-2301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Monoaminergic Degeneration and Ocular Motor Abnormalities in De Novo Parkinson's Disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-7348","authenticated-orcid":false,"given":"Kyung 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