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Dopamine replacement therapy (DRT) improves bradykinesia, but the response to DRT is multifaceted, comprising a short\u2010duration response (SDR) and a long\u2010duration response (LDR) only manifesting with chronic treatment. Prior experiments assessing motivation\u2010vigor coupling in PD used chronically treated subjects, obscuring the roles of the SDR and LDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To disambiguate the SDR and LDR, 11 de novo PD subjects (6 male\u2009[M]:5 female [F]; mean age, 67) were studied before treatment, after an acute levodopa (<jats:sc>l<\/jats:sc>\u2010dopa) dose, and in both the practical \u201c<jats:italic>off<\/jats:italic>\u201d (LDR) and \u201c<jats:italic>on<\/jats:italic>\u201d (LDR\u2009+\u2009SDR) states after chronic stable treatment. At each visit, subjects were characterized with a standard battery including the Movement Disorder Society\u2010Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) and an incentivized joystick task to assess motor performance in response to varying rewards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010Dopa induced a robust SDR and LDR, with further improvement in the combined SDR\u2009+\u2009LDR state. At baseline, after acute treatment (SDR), and after LDR induction, subjects did not exhibit the normal increase in movement speed with increasing reward. Only in the combined SDR\u2009+\u2009LDR state was there restoration of motivation\u2010vigor coupling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although consistent with prior results in chronically treated PD subjects, the significant improvement in motor performance observed with the SDR and LDR suggests that bradykinesia is not solely secondary to deficient modulation of motivational processes. \u00a9 2023 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29659","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T01:45:45Z","timestamp":1701999945000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Motivational Vigor in Parkinson's Disease Requires the Short and Long Duration 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