{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:31:08Z","timestamp":1793727068553,"version":"4.6.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010020770"],"award-info":[{"award-number":["MJFF\u2010020770"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG073526"],"award-info":[{"award-number":["K01AG073526"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder, but up\u2010to\u2010date epidemiological data are lacking in Latin America. We sought to estimate the prevalence and incidence of PD and parkinsonism in Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Medline, Embase, Scopus, Web of Science, Scientific Electronic Library Online, and Literatura Latino\u2010Americana e do Caribe em Ci\u00eancias da Sa\u00fade or the Latin American and Caribbean Health Science Literature databases for epidemiological studies reporting the prevalence or incidence of PD or parkinsonism in Latin America from their inception to 2022. Quality of studies was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Data were pooled via random\u2010effects meta\u2010analysis and analyzed by data source (cohort studies or administrative databases), sex, and age group. Significant differences between groups were determined by meta\u2010regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen studies from 13 Latin American countries were included in the review. Meta\u2010analyses of 17 studies (nearly 4\u2009million participants) found a prevalence of 472 (95% CI, 271\u2013820) per 100,000 and three studies an incidence of 31 (95% CI, 23\u201340) per 100,000 person\u2010years for PD; and seven studies found a prevalence of 4300 (95% CI, 1863\u20139613) per 100,000 for parkinsonism. The prevalence of PD differed by data source (cohort studies, 733 [95% CI, 427\u20131255] vs. administrative databases. 114 [95% CI, 63\u2013209] per 100,000,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), age group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), but not sex (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.73). PD prevalence in \u226560\u2009years also differed significantly by data source (cohort studies. 1229 [95% CI, 741\u20132032] vs. administrative databases, 593 [95% CI, 480\u2013733] per 100,000,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Similar patterns were observed for parkinsonism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The overall prevalence and incidence of PD in Latin America were estimated. PD prevalence differed significantly by the data source and age, but not sex. \u00a9 2023 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29682","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T01:26:06Z","timestamp":1702085166000},"page":"105-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prevalence and Incidence of Parkinson's Disease in Latin America: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6605-3338","authenticated-orcid":false,"given":"Dani J.","family":"Kim","sequence":"first","affiliation":[{"name":"Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience King's College London  London United Kingdom"},{"name":"Population Health Sciences Institute, Faculty of Medical Sciences Newcastle University  Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Isidro\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias National Institute of Neurology and Neurosurgery  Mexico City Mexico"},{"name":"National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Doering","sequence":"additional","affiliation":[{"name":"Bernard Becker Medical Library Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Llibre\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Dementia Research Unit Medical University of Havana  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Acosta","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias National Institute of Neurology and Neurosurgery  Mexico City Mexico"},{"name":"National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Rodriguez Salgado","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute University of San Francisco California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel D.","family":"Pinilla\u2010Monsalve","sequence":"additional","affiliation":[{"name":"Centre de Recherche, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California\u2010San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge J.","family":"Llibre\u2010Guerra","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Prina","sequence":"additional","affiliation":[{"name":"Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience King's College London  London United Kingdom"},{"name":"Population Health Sciences Institute, Faculty of Medical Sciences Newcastle University  Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30230-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120612"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012290"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00320-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00312-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1783"},{"key":"e_1_2_8_9_1","unstructured":"WHO.Parkinson disease; Accessed: November 24 2022. Available:https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25945"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445751"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0522"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_8_14_1","unstructured":"MunnZ MoolaS LisyK RiitanoD TufanaruC.JBI manual for evidence synthesis; JBI2020."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2020.8401"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.18273\/saluduis.53.e:21025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120210"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03683.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(03)00066-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20806"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.06.030"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517750"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1020-49892003000700005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.25100\/cm.v30i.2.126","article-title":"Prevalencia de las enfermedades neurol\u00f3gicas en el Valle del Cauca. Estudio Neuroepidemiol\u00f3gico Nacional (EPINEURO)","volume":"30","author":"Takeuchi Y","year":"1999","journal-title":"Colomb M\u00e9dica"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450490269444"},{"issue":"7","key":"e_1_2_8_29_1","first-page":"269","article-title":"Prevalence of Parkinson disease in an urban area of the ciudad de La Habana, province in Cuba. Door\u2010to\u2010door population study","volume":"16","author":"Giroud Benitez JL","year":"2000","journal-title":"Neurologia"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2021.100136"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-013-0181-y"},{"issue":"1","key":"e_1_2_8_32_1","first-page":"23","article-title":"Prevalencia de la Enfermedad de Parkinson: Estudio Puerta\u2010Puerta en la Provincia de Manab\u00ed\u2010Ecuador","volume":"26","author":"Montalvo Herdo\u00edza JP","year":"2017","journal-title":"Rev Ecuatoriana de Neurol"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.24875\/RMN.M19000043"},{"key":"e_1_2_8_34_1","first-page":"13","article-title":"Prevalence of Parkinson's disease 1n a population of Uruguay","volume":"69","author":"Chouza C","year":"1996","journal-title":"Adv Neurol"},{"key":"e_1_2_8_35_1","first-page":"191","article-title":"Estudio pioloto de la prevalencia de las principales enfermedades neurologicas en una poblacion del Uruguay","volume":"8","author":"Instituto de Neurologia Seccion Neuroepidemiologia","year":"1992","journal-title":"Rev Med Urug"},{"key":"e_1_2_8_36_1","unstructured":"ClarkeCEet al.\u2018UK Parkinson's disease society brain Bank diagnostic criteria\u2019 inclinical effectiveness and cost\u2010effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease: a large pragmatic randomised controlled trial (PD REHAB) NIHR Journals Library;2016. Accessed: June 14 2023. Available:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK379754\/."},{"key":"e_1_2_8_37_1","unstructured":"WHO protocol: epidemiologic studies of neurologic disorders;1982. Accessed: July 27 2023. Available:https:\/\/apps.who.int\/iris\/handle\/10665\/72410."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110696"},{"issue":"6","key":"e_1_2_8_39_1","first-page":"749","article-title":"A systematic review of the worldwide prevalence and incidence of Parkinson's disease","volume":"94","author":"Muangpaisan W","year":"2011","journal-title":"J Med Assoc Thail"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191683"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130675"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14094"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191763"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0020-6"},{"key":"e_1_2_8_45_1","unstructured":"TanLC.Epidemiology of Parkinson's Disease; Neurol. Asia2013."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-022-00793-7"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198736"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:25:56Z","timestamp":1760952356000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/mds.29682"],"URL":"https:\/\/doi.org\/10.1002\/mds.29682","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}