{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:32Z","timestamp":1782902072355,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acting on the main target of dopaminergic cells, the striatal \u03b3\u2010aminobutyric acid (GABA)\u2010ergic cells, might be a new way to treat persons with Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to assess the efficacy of bumetanide, an Na\u2013K\u2013Cl cotransporter (NKCC1) inhibitor, to improve motor symptoms in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 4\u2010month double\u2010blind, randomized, parallel\u2010group, placebo\u2010controlled trial of 1.75 to 3\u2009mg\/day bumetanide as an adjunct to levodopa in 44 participants with PD and motor fluctuations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the baseline, the mean change in OFF Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III score after 4\u2009months of treatment (primary endpoint) did not improve significantly compared with placebo. No changes between participants treated with bumetanide and those treated with placebo were observed for most other outcome measures. Despite no relevant safety signals, bumetanide was poorly tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no evidence in this study that bumetanide has efficacy in improving motor symptoms of PD. \u00a9 2024 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29726","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:18:56Z","timestamp":1706660336000},"page":"618-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Double\u2010Blind, Randomized, Placebo\u2010Controlled Trial of Bumetanide in Parkinson's Disease"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3869-0564","authenticated-orcid":false,"given":"Philippe","family":"Damier","sequence":"first","affiliation":[{"name":"CIC1413 NS\u2010Park\/FCRIN Network Nantes Universit\u00e9, CHU Nantes, INSERM  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5644-1292","authenticated-orcid":false,"given":"Bertrand","family":"Degos","sequence":"additional","affiliation":[{"name":"Neurology Department, Avicenne Hospital NS\u2010Park\/FCRIN Network INSERM U1050, CNRS UMR7241, Coll\u00e8ge de France, Centre de Recherche Interdisciplinaire en Biologie (CIRB), Universit\u00e9 PSL Sorbonne Paris Nord, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Castelonovo","sequence":"additional","affiliation":[{"name":"NS\u2010Park\/FCRIN Network CHU N\u00eemes  N\u00eemes 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