{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:16:51Z","timestamp":1788020211310,"version":"build-2784847793"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ventral intermediate nucleus of the thalamus (VIM) is an effective target for deep brain stimulation in tremor patients. Despite its therapeutic importance, its oscillatory coupling to cortical areas has rarely been investigated in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to identify the cortical areas coupled to the VIM in patients with essential tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We combined resting\u2010state magnetoencephalography with local field potential recordings from the VIM of 19 essential tremor patients. Whole\u2010brain maps of VIM\u2013cortex coherence in several frequency bands were constructed using beamforming and compared with corresponding maps of subthalamic nucleus (STN) coherence based on data from 19 patients with Parkinson's disease. In addition, we computed spectral Granger causality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The topographies of VIM\u2013cortex and STN\u2013cortex coherence were very similar overall but differed quantitatively. Both nuclei were coupled to the ipsilateral sensorimotor cortex in the high\u2010beta band; to the sensorimotor cortex, brainstem, and cerebellum in the low\u2010beta band; and to the temporal cortex, brainstem, and cerebellum in the alpha band. High\u2010beta coherence to sensorimotor cortex was stronger for the STN (<jats:italic>P<\/jats:italic>\u2009=\u20090.014), whereas low\u2010beta coherence to the brainstem was stronger for the VIM (<jats:italic>P<\/jats:italic>\u2009=\u20090.017). Although the STN was driven by cortical activity in the high\u2010beta band, the VIM led the\u00a0sensorimotor cortex in the alpha band.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thalamo\u2010cortical coupling is spatially and spectrally organized. The overall similar topographies of VIM\u2013cortex and STN\u2013cortex coherence suggest that functional connections are not necessarily unique to one subcortical structure but might reflect larger frequency\u2010specific networks involving VIM and STN to a different degree. \u00a9 2024 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29730","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:04:06Z","timestamp":1708495446000},"page":"684-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mapping Subcortico\u2010Cortical Coupling\u2014A Comparison of Thalamic and Subthalamic Oscillations"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6361-8101","authenticated-orcid":false,"given":"Alexandra","family":"Steina","sequence":"first","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sure","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Butz","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich Heine University  D\u00fcsseldorf 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