{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:23:11Z","timestamp":1775805791627,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54 NS116025"],"award-info":[{"award-number":["U54 NS116025"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results is sometimes challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim is to conduct an exploratory trial of oral dipraglurant for blepharospasm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was an exploratory, phase 2a, randomized, double\u2010blind, placebo\u2010controlled trial of 15 participants who were assigned to receive a placebo or dipraglurant (50 or 100\u2009mg) and assessed over 2\u2009days, 1 and 2\u2009hours following dosing. Outcome measures included multiple scales rated by clinicians or participants, digital video, and a wearable sensor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dipraglurant was well tolerated, with no obvious impact on any of the measurement outcomes. Power analyses suggested fewer subjects would be required for studies using a within\u2010subject versus independent group design, especially for certain measures. Some outcome measures appeared more suitable than others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although dipraglurant appeared well tolerated, it did not produce a trend for clinical benefit. The results provide valuable information for planning further trials in blepharospasm. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29734","type":"journal-article","created":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T02:59:27Z","timestamp":1707015567000},"page":"738-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An Exploratory, Randomized, <scp>Double\u2010Blind<\/scp> Clinical Trial of Dipraglurant for Blepharospasm"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-5706","authenticated-orcid":false,"given":"Gamze","family":"Kilic\u2010Berkmen","sequence":"first","affiliation":[{"name":"Department of Neurology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hodam","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of IEN Center for Human\u2010Centric Interfaces and Engineering The Institute for Electronics and Nanotechnology, Georgia Institute of Technology  Atlanta Georgia USA"},{"name":"Department of George W. 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