{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:31Z","timestamp":1772118751335,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030701","name":"Center for Advanced Research in Drying","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rapid eye movement (REM) sleep behavior disorder (RBD) is an early feature of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Damaging coding variants in Glucocerebrosidase (\n                      <jats:italic>GBA1<\/jats:italic>\n                      ) are a genetic risk factor for RBD. Recently, a population\u2010specific non\u2010coding risk variant (rs3115534) was found to be associated with PD risk and earlier onset in individuals of African ancestry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      We aimed to investigate whether the\n                      <jats:italic>GBA1<\/jats:italic>\n                      rs3115534 PD risk variant is associated with RBD in persons with PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied 709 persons with PD and 776 neurologically healthy controls from Nigeria. All DNA samples were genotyped and imputed, and the\n                      <jats:italic>GBA1<\/jats:italic>\n                      rs3115534 risk variant was extracted. The RBD screening questionnaire (RBDSQ) was used to assess symptoms of possible RBD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RBD was present in 200 PD (28.2%) and 51 (6.6%) controls. We identified that the non\u2010coding\n                      <jats:italic>GBA1<\/jats:italic>\n                      rs3115534 risk variant is associated with possible RBD in individuals of Nigerian origin (\u03b2,\u20090.3640; standard error [SE],\u20090.103,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20094.093e\u221204), as well as in all samples after adjusting for PD status (\u03b2,\u20090.2542; SE,\u20090.108;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.019) suggesting that although non\u2010coding, this variant may have the same downstream consequences as\n                      <jats:italic>GBA1<\/jats:italic>\n                      coding variants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results indicate that the non\u2010coding\n                      <jats:italic>GBA1<\/jats:italic>\n                      rs3115534 risk variant is associated with an increasing number of RBD symptoms in persons with PD of Nigerian origin. Further research is needed to assess if this variant is also associated with polysomnography\u2010defined RBD and with RBD symptoms in DLB. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29753","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T03:50:19Z","timestamp":1708660219000},"page":"728-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>GBA<\/i>\n                    1 rs3115534 Is Associated with\n                    <scp>REM<\/scp>\n                    Sleep Behavior Disorder in Parkinson's Disease in Nigerians"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-2653","authenticated-orcid":false,"given":"Oluwadamilola Omolara","family":"Ojo","sequence":"first","affiliation":[{"name":"College of Medicine, University of Lagos  Idi\u2010Araba, Lagos State Nigeria"},{"name":"Lagos University Teaching Hospital  Idi\u2010Araba, Lagos State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-1361","authenticated-orcid":false,"given":"Sara","family":"Bandres\u2010Ciga","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-1051","authenticated-orcid":false,"given":"Mary B.","family":"Makarious","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"},{"name":"UCL Movement Disorders Centre University College London  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-5716","authenticated-orcid":false,"given":"Peter Wild","family":"Crea","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"},{"name":"UCL Movement Disorders Centre University College London  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-9927","authenticated-orcid":false,"given":"Dena G.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-7777","authenticated-orcid":false,"given":"Henry","family":"Houlden","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-4449","authenticated-orcid":false,"given":"Mie","family":"Rizig","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-700X","authenticated-orcid":false,"given":"Andrew B.","family":"Singleton","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-5497","authenticated-orcid":false,"given":"Alastair J.","family":"Noyce","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health Queen Mary University London  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-4325","authenticated-orcid":false,"given":"Mike A.","family":"Nalls","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"},{"name":"DataTecnica LLC  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-8111","authenticated-orcid":false,"given":"Cornelis","family":"Blauwendraat","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-8803","authenticated-orcid":false,"given":"Njideka Ulunma","family":"Okubadejo","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Lagos  Idi\u2010Araba, Lagos State Nigeria"},{"name":"Lagos University Teaching Hospital  Idi\u2010Araba, Lagos State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Nigeria Parkinson's Disease Research Network and the Global Parkinson's Genetics Program (GP2)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901281"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0860-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28195"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00280-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306104"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34732-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00283-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28123"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12591"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.01.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.09.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13081146"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.228"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acw095"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11213-9"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:42:12Z","timestamp":1760949732000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/mds.29753"],"URL":"https:\/\/doi.org\/10.1002\/mds.29753","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.07.23298092","asserted-by":"object"}]},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"2023-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}