{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:26:12Z","timestamp":1787019972105,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","award":["NCT04288128"],"award-info":[{"award-number":["NCT04288128"]}],"id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["NCT04288128"],"award-info":[{"award-number":["NCT04288128"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With disease\u2010modifying drugs in reach for cerebellar ataxias, fine\u2010grained digital health measures are highly warranted to complement clinical and patient\u2010reported outcome measures in upcoming treatment trials and treatment monitoring. These measures need to demonstrate sensitivity to capture change, in particular in the early stages of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aim is to unravel gait measures sensitive to longitudinal change in the\u2014particularly trial\u2010relevant\u2014early stage of spinocerebellar ataxia type 2 (SCA2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a multicenter longitudinal study with combined cross\u2010sectional and 1\u2010year interval longitudinal analysis in early\u2010stage SCA2 participants (n\u2009=\u200923, including nine pre\u2010ataxic expansion carriers; median,\n                      <jats:italic>ATXN2<\/jats:italic>\n                      CAG repeat expansion 38\u2009\u00b1\u20092; median, Scale for the Assessment and Rating of Ataxia [SARA] score 4.8\u2009\u00b1\u20094.3). Gait was assessed using three wearable motion sensors during a 2\u2010minute walk, with analyses focused on gait measures of spatio\u2010temporal variability that have shown sensitivity to ataxia severity (eg, lateral step deviation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found significant changes for gait measures between baseline and 1\u2010year follow\u2010up with large effect sizes (lateral step deviation\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0001, effect size r\n                      <jats:sub>prb<\/jats:sub>\n                      \u2009=\u20090.78), whereas the SARA score showed no change (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.67). Sample size estimation indicates a required cohort size of n\u2009=\u200943 to detect a 50% reduction in natural progression. Test\u2013retest reliability and minimal detectable change analysis confirm the accuracy of detecting 50% of the identified 1\u2010year change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Gait measures assessed by wearable sensors can capture natural progression in early\u2010stage SCA2 within just 1\u2009year\u2014in contrast to a clinical ataxia outcome. Lateral step deviation represents a promising outcome measure for upcoming multicenter interventional trials, particularly in the early stages of cerebellar ataxia. \u00a9 2024 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29757","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T23:50:57Z","timestamp":1709164257000},"page":"788-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Digital Gait Measures Capture 1\u2010Year Progression in Early\u2010Stage Spinocerebellar Ataxia Type 2"],"prefix":"10.1002","volume":"39","author":[{"given":"Jens","family":"Seemann","sequence":"first","affiliation":[{"name":"Section Computational 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