{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:54:30Z","timestamp":1787496870639,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23 NS114167"],"award-info":[{"award-number":["K23 NS114167"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50 NS053488"],"award-info":[{"award-number":["P50 NS053488"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS082265"],"award-info":[{"award-number":["RO1 NS082265"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS115139"],"award-info":[{"award-number":["RO1 NS115139"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG010124"],"award-info":[{"award-number":["P30 AG010124"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19 AG062418"],"award-info":[{"award-number":["U19 AG062418"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The\n GPNMB<\/jats:italic>\n single\u2010nucleotide polymorphism rs199347 and\n GBA1<\/jats:italic>\n variants both associate with Lewy body disorder (LBD) risk.\n GPNMB<\/jats:italic>\n encodes glycoprotein nonmetastatic melanoma protein B (GPNMB), a biomarker for\n GBA1\u2010<\/jats:italic>\n associated Gaucher's disease.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study was to determine whether GPNMB levels (1) differ in LBD with and without\n GBA1<\/jats:italic>\n variants and (2) associate with rs199347 genotype.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We quantified GPNMB levels in plasma and cerebrospinal fluid (CSF) from 124 individuals with LBD with one\n GBA1<\/jats:italic>\n variant (121 plasma, 14 CSF), 631 individuals with LBD without\n GBA1<\/jats:italic>\n variants (626 plasma, 41 CSF), 9 neurologically normal individuals with one\n GBA1<\/jats:italic>\n variant (plasma), and 2 individuals with two\n GBA1<\/jats:italic>\n variants (plasma). We tested for associations between GPNMB levels and rs199347 or\n GBA1<\/jats:italic>\n status.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n GPNMB levels associate with rs199347 genotype in plasma (\n P<\/jats:italic>\n \u2009=\u20090.022) and CSF (\n P<\/jats:italic>\n \u2009=\u20090.007), but not with\n GBA1<\/jats:italic>\n status.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n rs199347 is a protein quantitative trait locus for GPNMB. GPNMB levels are unaltered in individuals carrying one\n GBA1<\/jats:italic>\n variant. \u00a9 2024 The Authors.\n Movement Disorders<\/jats:italic>\n published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.29773","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:28:05Z","timestamp":1712968085000},"page":"1065-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["GPNMB<\/scp>\n Biomarker Levels in\n \n GBA1<\/i>\n <\/scp>\n Carriers with Lewy Body Disorders"],"prefix":"10.1002","volume":"39","author":[{"given":"Eliza M.","family":"Brody","sequence":"first","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunji","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EunRan","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Amari","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney G.","family":"Hartstone","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Tyler","family":"Skrinak","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Diaz\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-7168","authenticated-orcid":false,"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Parkinson's Disease Research, Education, and Clinical Center Philadelphia Veterans Affairs Medical Center Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Tropea","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianna M.","family":"Van Deerlin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-2038","authenticated-orcid":false,"given":"Alice S.","family":"Chen\u2010Plotkin","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine, 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