{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:54:54Z","timestamp":1772744094913,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Progressive supranuclear palsy (PSP) is a rare 4R\u2010tauopathy. Transcranial direct current stimulation (tDCS) may improve specific symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This randomized, double\u2010blinded, sham\u2010controlled trial aimed at verifying the short\u2010, mid\u2010, and long\u2010term effect of multiple sessions of anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) cortex in PSP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients were randomly assigned to active or sham stimulation (2\u2009mA for 20\u2009minute) for 5\u2009days\/week for 2\u2009weeks. Participants underwent assessments at baseline, after the 2\u2010week stimulation protocol, then after 45\u2009days and 3\u2009months from baseline. Primary outcomes were verbal and semantic fluency. The efficacy was verified with analysis of covariance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We failed to detect a significant effect of active stimulation on primary outcomes. Stimulation was associated to worsening of specific behavioral complaints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 2\u2010week protocol of anodal left DLPFC tDCS is not effective in PSP. Specific challenges in running symptomatic clinical trials with classic design are highlighted. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29774","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:39:01Z","timestamp":1710214741000},"page":"1043-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Direct Current Stimulation of Prefrontal Cortex Is Not Effective in <scp>Progressive Supranuclear Palsy<\/scp>: A Randomized Trial"],"prefix":"10.1002","volume":"39","author":[{"given":"Arianna","family":"Cappiello","sequence":"first","affiliation":[{"name":"Center for Neurodegenerative diseases (CEMAND), Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  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