{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:50:53Z","timestamp":1790283053225,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gait disorders in patients with Parkinson's disease (PD) can become disabling with disease progression without effective treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the efficacy of intermittent \u03b8 burst trans\u2010spinal magnetic stimulation (TsMS) in PD patients with gait and balance disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, parallel, double\u2010blind, controlled trial. Active or sham TsMS was applied at third thoracic vertebra with 100% of the trans\u2010spinal motor threshold, during 5 consecutive days. Participants were evaluated at baseline, immediately after last session, 1 and 4\u2009weeks after last session. Primary outcome was Total Timed Up and Go (TUG) values comparing active versus sham phases 1\u2009week after intervention. The secondary outcome measurements consisted of motor, gait and balance scales, and questionnaires for quality of life and cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were included, average age 68.5 (6.4) years in active group and 70.3 (6.3) years in sham group. In active group, Total TUG mean baseline was 107.18 (95% CI, 52.1\u2013116.1), and 1\u2009week after stimulation was 93.0 (95% CI, 50.7\u2013135.3); sham group, Total TUG mean baseline was 101.2 (95% CI, 47.1\u2013155.3) and 1\u2009week after stimulation 75.2 (95% CI 34.0\u2013116.4), <jats:italic>P<\/jats:italic>\u2009=\u20090.54. Similarly, intervention had no significant effects on secondary outcome measurements. During stimulation period, five patients presented with mild side effects (three in active group and two in sham group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>TsMS did not significantly improve gait or balance analysis in patients with PD and gait disorders. The protocol was safe and well tolerated. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29776","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T05:58:51Z","timestamp":1710309531000},"page":"1048-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trans\u2010Spinal Theta Burst Magnetic Stimulation in Parkinson's Disease and Gait Disorders"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3332-5940","authenticated-orcid":false,"given":"Jana\u00edna Reis","family":"Menezes","sequence":"first","affiliation":[{"name":"Movement Disorders Center, Department of Neurology, School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo 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