{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:57Z","timestamp":1791288957918,"version":"4.3.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Essential tremor (ET) affects numerous adults, impacting quality of life (QOL) and often defying pharmacological treatment. Surgical interventions like deep brain stimulation (DBS) and lesional approaches, including radiofrequency, gamma\u2010knife radiosurgery, and magnetic resonance imaging (MRI)\u2013guided focused ultrasound, offer solutions but are not devoid of limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This retrospective, single\u2010center, single\u2010blinded pilot study aimed to assess the safety and efficacy of unilateral MRI\u2010guided laser interstitial thermal therapy (MRIg\u2010LITT) thalamotomy for medically intractable ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine patients with ET, unresponsive to medications and unsuitable for DBS, underwent unilateral MRIg\u2010LITT thalamotomy. We assessed tremor severity, QOL, cognitive function, and adverse events (AE) over a 12\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tremor severity significantly improved, with a reduction of 83.37% at 12\u2009months post\u2010procedure. QOL scores improved by 74.60% at 12\u2009months. Reported AEs predominantly included transient dysarthria, proprioceptive disturbances, and gait balance issues, which largely resolved within a month. At 3\u2009months, 2 patients (22%) exhibited contralateral hemiparesis requiring physiotherapy, with 1 patient (11%) exhibiting persistent hemiparesis at 12\u2009months. No significant cognitive impairment was detected post\u2010procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unilateral MRIg\u2010LITT thalamotomy yielded substantial and enduring tremor alleviation and enhanced QOL in patients with ET that is resistant to medication. The AE profile was acceptable. Our findings support the need for additional research with expanded patient cohorts and extended follow\u2010up to corroborate these outcomes and to refine the role of MRIg\u2010LITT as a targeted and minimally invasive approach for ET management. \u00a9 2024 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29790","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:20:15Z","timestamp":1711502415000},"page":"1006-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unilateral Magnetic Resonance Imaging\u2013Guided Laser Interstitial Thermal Therapy Thalamotomy for Essential Tremor"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-1128","authenticated-orcid":false,"given":"Mickael","family":"Aubignat","sequence":"first","affiliation":[{"name":"Department of Neurology and Movement Disorders Amiens Picardie University Hospital  Amiens France"},{"name":"Expert Center for Parkinson's Disease Amiens Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Tir","sequence":"additional","affiliation":[{"name":"Department of Neurology and Movement Disorders Amiens Picardie University Hospital  Amiens France"},{"name":"Expert Center for Parkinson's Disease Amiens Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martial","family":"Ouendo","sequence":"additional","affiliation":[{"name":"Expert Center for Parkinson's Disease Amiens Picardie University Hospital  Amiens 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