{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:22:36Z","timestamp":1792282956364,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["2021"],"award-info":[{"award-number":["2021"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent studies identified increased cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker for parkinsonian disorders, suggesting a compensation to dying dopaminergic neurons. A correlation with 123I\u2010FP\u2010CIT\u2010SPECT (DaT\u2010SPECT) imaging could shed light on this link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective is to assess the relationship between CSF DDC levels and DaT\u2010SPECT binding values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 51 and 72 Parkinson's disease (PD) subjects with available DaT\u2010SPECT and CSF DDC levels were selected from the PPMI and Biopark cohorts, respectively. DDC levels were analyzed using proximity extension assay and correlated with DaT\u2010SPECT striatal binding ratios (SBR). All analyses were corrected for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CSF DDC levels in PD patients correlated negatively with DaT\u2010SPECT SBR in both putamen and caudate nucleus. Additionally, SBR decreased with increased DDC levels over time in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      CSF DDC levels negatively correlate with DaT\u2010SPECT SBR in levodopa\u2010treated PD. \u00a9 2024 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29835","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T01:59:20Z","timestamp":1716775160000},"page":"1881-1885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased\n                    <scp>CSF DOPA<\/scp>\n                    Decarboxylase Correlates with Lower\n                    <scp>DaT\u2010SPECT<\/scp>\n                    Binding: Analyses in Biopark and\n                    <scp>PPMI<\/scp>\n                    Cohorts"],"prefix":"10.1002","volume":"39","author":[{"given":"Shervin","family":"Khosousi","sequence":"first","affiliation":[{"name":"Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sturchio","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Appleton","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-4547","authenticated-orcid":false,"given":"Wojciech","family":"Paslawski","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-3841","authenticated-orcid":false,"given":"Michael","family":"Ta","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"DataTecnica LLC  Washington District of Columbia USA"},{"name":"Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nalls","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"DataTecnica LLC  Washington District of Columbia USA"},{"name":"Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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