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The apoptotic effect of a protein containing a long polyserine tract on SK\u2010N\u2010MC cells was evaluated using caspase 3\/7 activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CAG repeat expansion increases the expression of the\n                      <jats:italic>PPP2R2B 7B7D<\/jats:italic>\n                      transcript, as well as B\u03b21 protein, in an SK\u2010N\u2010MC cell model in which the full\u2010length\n                      <jats:italic>PPP2R2B 7B7D<\/jats:italic>\n                      transcript is overexpressed. The CAG repeat expansion within the\n                      <jats:italic>7B7D<\/jats:italic>\n                      transcript is translated into a long polyserine tract that triggers apoptosis in SK\u2010N\u2010MC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The SCA12 mutation leads to overexpression of\n                      <jats:italic>PPP2R2B B\u03b21<\/jats:italic>\n                      and to expression of a protein containing a long polyserine tract; both these effects potentially contribute to SCA12 pathogenesis. \u00a9 2024 International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  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Neurobiology, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-6348","authenticated-orcid":false,"given":"Pan P.","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland 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