{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:22:10Z","timestamp":1787674930472,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31NS115363"],"award-info":[{"award-number":["F31NS115363"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Responsive deep brain stimulation (rDBS) uses physiological signals to deliver stimulation when needed. rDBS is hypothesized to reduce stimulation\u2010induced speech effects associated with continuous DBS (cDBS) in patients with essential tremor (ET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if rDBS reduces cDBS speech\u2010related side effects while maintaining tremor suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight ET participants with thalamic DBS underwent unilateral rDBS. Both speech evaluations and tremor severity were assessed across three conditions (DBS OFF, cDBS ON, and rDBS ON). Speech was analyzed using intelligibility ratings. Tremor severity was scored using the Fahn\u2010Tolosa\u2010Marin Tremor Rating Scale (TRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During unilateral cDBS, participants experienced reduced speech intelligibility (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.025) compared to DBS OFF. rDBS was not associated with a deterioration of intelligibility. Both rDBS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.026) and cDBS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.038) improved the contralateral TRS score compared to DBS OFF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>rDBS maintained speech intelligibility without loss of tremor suppression. A larger prospective chronic study of rDBS in ET is justified. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29865","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T03:08:51Z","timestamp":1718420931000},"page":"1619-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Responsive Versus Continuous Deep Brain Stimulation for Speech in Essential Tremor: A Pilot Study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6885-6791","authenticated-orcid":false,"given":"Stephanie","family":"Cernera","sequence":"first","affiliation":[{"name":"J. Crayton Pruitt Department of Biomedical Engineering  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Long","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Department of Biomedical Engineering  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Kelberman","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Department of Biomedical Engineering  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen W.","family":"Hegland","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Neurologic Rehabilitation Stanford Neuroscience Health Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Smith\u2010Hublou","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"de Hemptinne","sequence":"additional","affiliation":[{"name":"Department of Neurology Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson N.","family":"Cagle","sequence":"additional","affiliation":[{"name":"Department of Neurology Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly D.","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"Department of Neurology Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Gunduz","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Department of Biomedical Engineering  Gainesville Florida USA"},{"name":"Department of Neurology Norman Fixel Institute for Neurological Diseases  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.46.4.1150"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199909)14:5<847::aid-mds1021>3.0.co;2-g"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191359"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.4.506"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26924"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23195"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27700"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1737017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.09.021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23951"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aabc9b"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay7680"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.633655"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.09.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313518"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.07.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2012.00117"},{"key":"e_1_2_9_19_1","volume-title":"Voice and Articulation Drillbook","author":"Fairbanks G","year":"1960"},{"key":"e_1_2_9_20_1","volume-title":"Motor Speech Disorders","author":"Duffy JR"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000266338"},{"key":"e_1_2_9_22_1","volume-title":"Parkinson's Disease and Movement Disorders","author":"Jankovic J","year":"2007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1909471"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/1\/016009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28098"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25958"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13234"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2019.104724"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12546"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.29865","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:53:34Z","timestamp":1787673214000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/mds.29865"],"URL":"https:\/\/doi.org\/10.1002\/mds.29865","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]},"assertion":[{"value":"2024-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}