{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:01:50Z","timestamp":1790996510175,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Among the different types of pain related to Parkinson's disease (PD), parkinsonian central pain (PCP) is the most disabling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the analgesic efficacy of two therapeutic strategies (opioid with oxycodone\u2010 prolonged\u2010release (PR) and higher dose of levodopa\/benserazide) compared with placebo in patients with PCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>OXYDOPA was a randomized, double\u2010blind, double\u2010dummy, placebo\u2010controlled, multicenter parallel\u2010group trial run at 15 centers within the French NS\u2010Park network. PD patients with PCP (\u226530 on the Visual Analogue Scale [VAS]) were randomly assigned to receive oxycodone\u2010PR (up to 40\u2009mg\/day), levodopa\/benserazide (up to 200\u2009mg\/day) or matching placebo three times a day (tid) for 8\u2009weeks at a stable dose, in add\u2010on to their current dopaminergic therapy. The primary endpoint was the change in average pain intensity over the previous week rated on VAS from baseline to week\u201010 based on modified intention\u2010to\u2010treat analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between May 2016 and August 2020, 66 patients were randomized to oxycodone\u2010PR (n\u2009=\u200923), levodopa\/benserazide (n\u2009=\u200920) or placebo (n\u2009=\u200923). The mean change in pain intensity was \u221217\u2009\u00b1\u200918.5 on oxycodone\u2010PR, \u22128.3\u2009\u00b1\u200911.1 on levodopa\/benserazide, and \u221214.3\u2009\u00b1\u200918.9 in the placebo groups. The absolute difference versus placebo was \u22121.54 (97.5% confidence interval [CI], \u221217.0 to 13.90;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.8) on oxycodone\u2010PR and +7.79 (97.5% CI, \u22124.99 to 20.58;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.2) on levodopa\/benserazide. Similar proportions of patients in each group experienced all\u2010cause adverse events. Those leading to study discontinuation were most frequently observed with oxycodone\u2010PR (39%) than levodopa\/benserazide (5%) or placebo (15%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The present trial failed to demonstrate the superiority of oxycodone\u2010PR or a higher dose of levodopa in patients with PCP, while oxycodone\u2010PR was poorly tolerated. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29878","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T04:49:36Z","timestamp":1717822176000},"page":"1533-1543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain:\n                    <scp>OXYDOPA<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7262-2338","authenticated-orcid":false,"given":"Christine","family":"Brefel\u2010Courbon","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Centre, Centre d'Investigation Clinique CIC1436 University Hospital of Toulouse, NeuroToul COEN Centre, NS\u2010PARK\/FCRIN Network  Toulouse France"},{"name":"Toulouse Neuroimaging Centre (TONIC) UMR1214 INSERM\/UT3  Toulouse 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Lille Neuroscience and Cognition, Inserm, INSERM UMR\u2010S1172 CHU de Lille LICEND COEN Center Lille NS\u2010Park Network  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Thalamas","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Methodology Data management and Statistical Analysis Unit, Centre d'Investigation Clinique CIC1436 University Hospital of Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Methodology Data management and Statistical Analysis Unit, Centre d'Investigation Clinique CIC1436 University Hospital of Toulouse  Toulouse 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Laboratoire de Neurosciences Fonctionnelles et Pathologie (LNFP) Universit\u00e9 de Picardie Jules Verne University of Picardy Jules Verne (UPJV), NS\u2010PARK\/FCRIN Network  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Thobois","sequence":"additional","affiliation":[{"name":"Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, Facult\u00e9 de M\u00e9decine Lyon Sud Charles M\u00e9rieux, CNRS, Institut des Sciences Cognitives, UMR 5229  Bron France"},{"name":"Centre Expert Parkinson H\u00f4pital Neurologique \u201cPierre Wertheimer\u201d, Hospices Civils de Lyon, NS\u2010PARK\/FCRIN Network  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayet","family":"Salhi","sequence":"additional","affiliation":[{"name":"Centre Expert Parkinson, Neurologie, and Equipe 01 NPI IMRB; CHU Henri Mondor, AP\u2010HP, INSERM et Facult\u00e9 de Sant\u00e9 Universit\u00e9 Paris\u2010Est Cr\u00e9teil  Cr\u00e9teil 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