{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:30:35Z","timestamp":1792510235661,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015997","name":"Deutsche Gesellschaft f\u00fcr Parkinson und Bewegungsst\u00f6rungen","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy\u2013ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy\u2013ID 390857198"]}],"id":[{"id":"10.13039\/100015997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Multiple system atrophy is a neurodegenerative disease with \u03b1\u2010synuclein aggregation in glial cytoplasmic inclusions, leading to dysautonomia, parkinsonism, and cerebellar ataxia.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of this study was to validate the accuracy of the International Parkinson and Movement Disorder Society Multiple System Atrophy clinical diagnostic criteria, particularly considering the impact of the newly introduced brain magnetic resonance imaging (MRI) markers.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Diagnostic accuracy of the clinical diagnostic criteria for multiple system atrophy was estimated retrospectively in autopsy\u2010confirmed patients with multiple system atrophy, Parkinson's disease, progressive supranuclear palsy, and corticobasal degeneration.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We identified a total of 240 patients. Sensitivity of the clinically probable criteria was moderate at symptom onset but improved with disease duration (year 1: 9%, year 3: 39%, final ante mortem record: 77%), whereas their specificity remained consistently high (99%\u2013100% throughout). Sensitivity of the clinically established criteria was low during the first 3\u2009years (1%\u20139%), with mild improvement at the final ante mortem record (22%), whereas specificity remained high (99%\u2013100% throughout). When MRI features were excluded from the clinically established criteria, their sensitivity increased considerably (year 1: 3%, year 3: 22%, final ante mortem record: 48%), and their specificity was not compromised (99%\u2013100% throughout).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The International Parkinson and Movement Disorder Society multiple system atrophy diagnostic criteria showed consistently high specificity and low to moderate sensitivity throughout the disease course. The MRI markers for the clinically established criteria reduced their sensitivity without improving specificity. Combining clinically probable and clinically established criteria, but disregarding MRI features, yielded the best sensitivity with excellent specificity and may be most appropriate to select patients for therapeutic trials. \u00a9 2024 The Author(s).\n Movement Disorders<\/jats:italic>\n published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.29879","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:50:52Z","timestamp":1717746652000},"page":"1514-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0270-0029","authenticated-orcid":false,"given":"Ida","family":"Wilkens","sequence":"first","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Heine","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria C.","family":"Ruf","sequence":"additional","affiliation":[{"name":"Center for Neuropathology and Prion Research, Faculty of Medicine, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslau","family":"Compta","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service, Institut Cl\u00ednic de Neuroci\u00e8ncies, Hospital Cl\u00ednic de Barcelona, IDIBAPS, CIBERNED Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Molina","family":"Porcel","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Clinic, IDIBAPS Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Troakes","sequence":"additional","affiliation":[{"name":"Basic and Clinical Neuroscience Department Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Vamanu","sequence":"additional","affiliation":[{"name":"Basic and Clinical Neuroscience Department Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Downes","sequence":"additional","affiliation":[{"name":"Basic and Clinical Neuroscience Department Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2554-5181","authenticated-orcid":false,"given":"Jesse","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"},{"name":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Neurology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Englund","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Pathology instead of Neurology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Nemati","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3512-5984","authenticated-orcid":false,"given":"Sabrina","family":"Katzdobler","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Feodor\u2010Lynen\u2010Strasse 17 Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Feodor\u2010Lynen\u2010Strasse 17 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-7485","authenticated-orcid":false,"given":"Alex","family":"Pantelyat","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Seemiller","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Dopper","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Rozenmuller","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program and Krembil Brain Institute University Health Network Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-5667","authenticated-orcid":false,"given":"Nathaniel","family":"Bendahan","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease and the Rossy Progressive Supranuclear Palsy Centre, Division of Neurology Toronto Western Hospital, University Health Network and the University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease and the Rossy Progressive Supranuclear Palsy Centre, Division of Neurology Toronto Western Hospital, University Health Network and the University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Herms","sequence":"additional","affiliation":[{"name":"Center for Neuropathology and Prion Research, Faculty of Medicine, LMU Munich Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Feodor\u2010Lynen\u2010Strasse 17 Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Feodor\u2010Lynen\u2010Strasse 17 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-6187","authenticated-orcid":false,"given":"G\u00fcnter","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Feodor\u2010Lynen\u2010Strasse 17 Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Feodor\u2010Lynen\u2010Strasse 17 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-0281","authenticated-orcid":false,"given":"Franziska","family":"Hopfner","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1311488"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29164"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70327-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.589"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.10.006"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"61","article-title":"The differential diagnosis and treatment of atypical parkinsonism","volume":"113","author":"Levin J","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00382-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00697-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26715"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0672-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.434"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf080"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001807"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70288-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30141-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl021"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002985"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23601"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.10.002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207905"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29304"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00907.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70238-8"},{"issue":"2","key":"e_1_2_9_27_1","article-title":"Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration","volume":"246","author":"Dickson DW","year":"1999","journal-title":"J Neurol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2015"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12208"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.11.935"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2006.03716.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2018.345"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000417"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.12.001"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24968"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13052"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.29879","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.29879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:53:29Z","timestamp":1787673209000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,7]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/mds.29879"],"URL":"https:\/\/doi.org\/10.1002\/mds.29879","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,7]]},"assertion":[{"value":"2024-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}