{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:51:39Z","timestamp":1793479899320,"version":"4.5.0"},"reference-count":194,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent \u03b1\u2010synuclein (\u03b1Syn) aggregation in affected brain regions. However, the role of \u03b1Syn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of \u03b1Syn, either primary or secondary, is critical for developing disease\u2010modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. \u00a9 2024 The Author(s).\n                    <jats:italic>Movement Disorders<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                  <\/jats:p>","DOI":"10.1002\/mds.29897","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:20:57Z","timestamp":1719800457000},"page":"1663-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Research Priorities on the Role of \u03b1\u2010\n                    <scp>Synuclein<\/scp>\n                    in Parkinson's Disease Pathogenesis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-248X","authenticated-orcid":false,"given":"Jacqueline","family":"Burr\u00e9","sequence":"first","affiliation":[{"name":"Appel Institute for Alzheimer's Disease Research and Brain and Mind Research Institute, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-3260","authenticated-orcid":false,"given":"Robert H.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurology University of California, San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-8398","authenticated-orcid":false,"given":"Glenda","family":"Halliday","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, School of Medical Sciences, The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-3667","authenticated-orcid":false,"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Edmond J. 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