{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:42:48Z","timestamp":1790113368411,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Patients in late\u2010stage Parkinson's disease (PD\n                      <jats:sub>LS<\/jats:sub>\n                      ) are caregiver\u2010dependent, have low quality of life, and higher healthcare costs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To estimate the prevalence of PD\n                      <jats:sub>LS<\/jats:sub>\n                      patients in the current US healthcare system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We downloaded the 2010\u20132022 data from the TriNetX Diamond claims network that consists of 92 US healthcare sites. PD was identified using standard diagnosis codes, and PD\n                      <jats:sub>LS<\/jats:sub>\n                      was identified by the usage of wheelchair dependence, personal care assistance, and\/or presence of diagnoses of dementia. Age of PD\n                      <jats:sub>LS<\/jats:sub>\n                      identification and survival information were obtained and stratified by demographic and the disability subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 1,031,377 PD patients in the TriNetX database. Of these, 18.8% fitted our definition of PD\n                      <jats:sub>LS<\/jats:sub>\n                      (n\u2009=\u2009194,297), and 10.2% met two or more late\u2010stage criteria. Among all PD\n                      <jats:sub>LS<\/jats:sub>\n                      , the mean age of PD\n                      <jats:sub>LS<\/jats:sub>\n                      identification was 78.1 (\u00b17.7) years, and 49% were already reported as deceased. PD\n                      <jats:sub>LS<\/jats:sub>\n                      patients were predominantly male (58.5%) with similar distribution across PD\n                      <jats:sub>LS<\/jats:sub>\n                      subgroups. The majority did not have race (71%) or ethnicity (69%) information, but for the available information &gt;90% (n\u2009=\u200953,162) were White, 8.2% (n\u2009=\u20095121) Hispanic\/Latino, 7.8% (n\u2009=\u20094557) Black, and &lt;0.01% (n\u2009=\u2009408) Asian. Of the PD\n                      <jats:sub>LS<\/jats:sub>\n                      cohort, 71.6% identified with dementia, 12.9% had personal care assistance, and 4.8% were wheelchair\u2010bound.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Late\u2010stage patients are a significant part of the PD landscape in the current US healthcare system, and largely missed by traditional motor\u2010based disability staging. It is imperative to include this population as a clinical, social, and research priority. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29900","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T05:50:53Z","timestamp":1720072253000},"page":"1592-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of Late\u2010Stage Parkinson's Disease in the\n                    <scp>US<\/scp>\n                    Healthcare System: Insights from\n                    <scp>TriNetX<\/scp>"],"prefix":"10.1002","volume":"39","author":[{"given":"Sol","family":"De Jesus","sequence":"first","affiliation":[{"name":"Department of Neurology Pennsylvania State University\u2010Milton S. 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