{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:47:10Z","timestamp":1793249230851,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG000535"],"award-info":[{"award-number":["AG000535"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["ZIA AG000949"],"award-info":[{"award-number":["ZIA AG000949"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["ZIA NS003154"],"award-info":[{"award-number":["ZIA NS003154"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010009421\/17483"],"award-info":[{"award-number":["MJFF\u2010009421\/17483"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Commercial genome\u2010wide genotyping arrays have historically neglected coverage of genetic variation across populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to create a multi\u2010ancestry genome\u2010wide array that would include a wide range of neuro\u2010specific genetic content to facilitate genetic research in neurological disorders across multiple ancestral groups, fostering diversity and inclusivity in research studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed the Illumina NeuroBooster Array (NBA), a custom high\u2010throughput and cost\u2010effective platform on a backbone of 1,914,934 variants from the Infinium Global Diversity Array and added custom content comprising 95,273 variants associated with more than 70 neurological conditions or traits, and we further tested its performance on more than 2000 patient samples. This novel platform includes approximately 10,000 tagging variants to facilitate imputation and analyses of neurodegenerative disease\u2013related genome\u2010wide association study loci across diverse populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this article, we describe NBA's potential as an efficient means for researchers to assess known and novel disease genetic associations in a multi\u2010ancestry framework. The NBA can identify rare genetic variants and accurately impute more than 15\u2009million common variants across populations. Apart from enabling sample prioritization for further whole\u2010genome sequencing studies, we envisage that NBA will play a pivotal role in recruitment for interventional studies in the precision medicine space.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      From a broader perspective, the NBA serves as a promising means to foster collaborative research endeavors in the field of neurological disorders worldwide. Ultimately, this carefully designed tool is poised to make a substantial contribution to uncovering the genetic etiology underlying these debilitating conditions. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29902","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T10:30:23Z","timestamp":1726482623000},"page":"2039-2048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["<scp>NeuroBooster<\/scp>\n                    Array: A Genome\u2010Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-1361","authenticated-orcid":false,"given":"Sara","family":"Bandres\u2010Ciga","sequence":"first","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz","family":"Faghri","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland USA"},{"name":"Data Tecnica  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Majounie","sequence":"additional","affiliation":[{"name":"Illumina Inc  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Koretsky","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health  Bethesda Maryland 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