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There is an urgent need for biomarkers to aid early intervention and neuroprotection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim is to assess quantitative motor, cognitive, and brain magnetic resonance imaging (MRI) characteristics in iRBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010eight polysomnography\u2010confirmed iRBD patients and 28 age\u2010 and sex\u2010matched healthy controls underwent clinical, cognitive, and motor functional evaluations, along with brain MRI. Motor tasks included nine\u2010hole peg test, five\u2010times\u2010sit\u2010to\u2010stand test, timed\u2010up\u2010and\u2010go test, and 4\u2010meter walking test with and without cognitive dual task. Quantitative spatiotemporal gait parameters were obtained using an optoelectronic system. Brain MRI analysis included functional connectivity (FC) of the main resting\u2010state networks, gray matter (GM) volume using voxel\u2010based morphometry, cortical thickness, and deep GM and brainstem volumes using FMRIB's Integrated Registration and Segmentation Tool and FreeSurfer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>iRBD patients relative to healthy subjects exhibited a poorer performance during the nine\u2010hole peg test and five\u2010times\u2010sit\u2010to\u2010stand test, and greater asymmetry of arm\u2010swing amplitude and stride length variability during dual\u2010task gait. Dual task significantly worsened the walking performance of iRBD patients more than healthy controls. iRBD patients exhibited nonmotor symptoms, and memory, abstract reasoning, and visuospatial deficits. iRBD patients exhibited decreased FC of pallidum and putamen within the basal ganglia network and occipital and temporal areas within the visuo\u2010associative network, and a reduced volume of the supramarginal gyrus. Brain functional alterations correlated with gait changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Subtle motor and nonmotor alterations were identified in iRBD patients, alongside brain structural and functional MRI changes. These findings may represent early signs of neurodegeneration and contribute to the development of predictive models for progression to parkinsonism. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29911","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T05:16:38Z","timestamp":1720070198000},"page":"1567-1577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gait Analysis and Magnetic Resonance Imaging Characteristics in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder"],"prefix":"10.1002","volume":"39","author":[{"given":"Elisabetta","family":"Sarasso","sequence":"first","affiliation":[{"name":"Neuroimaging 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