{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:48:05Z","timestamp":1791319685557,"version":"4.3.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Until recently, about three\u2010quarters of all monogenic Parkinson's disease (PD) studies were performed in European\/White ancestry, thereby severely limiting our insights into genotype\u2013phenotype relationships at a global scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the multi\u2010ancestry spectrum of monogenic PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The first systematic approach to embrace monogenic PD worldwide, The Michael J. Fox Foundation Global Monogenic PD Project, contacted authors of publications reporting individuals carrying pathogenic variants in known PD\u2010causing genes. In contrast, the Global Parkinson's Genetics Program's Monogenic Network took a different approach by targeting PD centers underrepresented or not yet represented in the medical literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this article, we describe combining both efforts in a merger project resulting in a global monogenic PD cohort with the buildup of a sustainable infrastructure to identify the multi\u2010ancestry spectrum of monogenic PD and enable studies of factors modifying penetrance and expressivity of monogenic PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This effort demonstrates the value of future research based on team science approaches to generate comprehensive and globally relevant results. \u00a9 2024 State of New South Wales and The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.29925","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T05:16:50Z","timestamp":1722316610000},"page":"1868-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-9569","authenticated-orcid":false,"given":"Johanna","family":"Junker","sequence":"first","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck  Luebeck Germany"},{"name":"Department of Neurology University Clinic Schleswig\u2010Holstein  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M.","family":"Lange","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck  Luebeck Germany"},{"name":"Department of Neurology University Clinic Schleswig\u2010Holstein  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Juliane","family":"Vollstedt","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6040-2531","authenticated-orcid":false,"given":"Karisha","family":"Roopnarain","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Free State  Bloemfontein South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Leila M.","family":"Doquenia","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azlina Ahmad","family":"Annuar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine, University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-9921","authenticated-orcid":false,"given":"Micol","family":"Avenali","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-3438","authenticated-orcid":false,"given":"Soraya","family":"Bardien","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences Faculty of Medicine and Health Sciences, Stellenbosch University  Cape Town South 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