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isolated dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to perform a large\u2010scale GWAS in a well\u2010characterized, multicenter sample of &gt;6000 individuals to identify genetic risk factors for isolated dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Array\u2010based GWASs were performed on autosomes for 4303 dystonia participants and 2362 healthy control subjects of European ancestry with subgroup analysis based on age at onset, affected body regions, and a newly developed clinical score. Another 736 individuals were used for validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This GWAS identified no common genome\u2010wide significant loci that could be replicated despite sufficient power to detect meaningful effects. Power analyses imply that the effects of individual variants are likely very small.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Moderate single\u2010nucleotide polymorphism\u2013based heritability indicates that common variants do not contribute to isolated dystonia in this cohort. Sequence\u2010based GWASs (eg, by whole\u2010genome sequencing) might help to better understand the genetic basis. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29968","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T14:28:14Z","timestamp":1726583294000},"page":"2110-2116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic Risk Factors in Isolated Dystonia Escape Genome\u2010Wide Association Studies"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-5738","authenticated-orcid":false,"given":"Bj\u00f6rn\u2010Hergen","family":"Laabs","sequence":"first","affiliation":[{"name":"Institute of Medical Biometry and Statistics, University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Lohmann","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva\u2010Juliane","family":"Vollstedt","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Reinberger","sequence":"additional","affiliation":[{"name":"Institute for Cardiogenetics, University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-6638","authenticated-orcid":false,"given":"Lisa\u2010Marie","family":"Nuxoll","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Statistics, University of L\u00fcbeck  L\u00fcbeck 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