{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:23:06Z","timestamp":1790698986895,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["2021\u20131516"],"award-info":[{"award-number":["2021\u20131516"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021790","name":"Fondation pour la Recherche sur Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dementia with Lewy bodies (DLB) is characterized by a marked shift of electroencephalographic (EEG) power and dominant rhythm, from the \u03b1 toward the \u03b8 frequency range. Transcranial alternate current stimulation (tACS) is a non\u2010invasive brain stimulation technique that allows entrainment of cerebral oscillations at desired frequencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our goal is to evaluate the effects of occipital \u03b1\u2010tACS on cognitive functions and neurophysiological measures in patients with DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a double\u2010blind, randomized, sham\u2010controlled, cross\u2010over clinical trial in 14 participants with DLB. Participants were randomized to receive either \u03b1\u2010tACS (60\u2009minutes of 3\u2009mA peak\u2010to\u2010peak stimulation at 12\u2009Hz) or sham stimulation applied over the occipital cortex. Clinical evaluations were performed to assess visuospatial and executive functions, as well as verbal episodic memory. Neurophysiological assessments and EEG recordings were conducted at baseline and following both \u03b1\u2010tACS and sham stimulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Occipital \u03b1\u2010tACS was safe and well\u2010tolerated. We observed a significant enhancement in visuospatial abilities and executive functions, but no improvement in verbal episodic memory. We observed an increase in short latency afferent inhibition, a neurophysiological marker indirectly and partially dependent on cholinergic transmission, coinciding with an increase in \u03b1 power and a decrease in \u0394 power following \u03b1\u2010tACS stimulation, effects not seen with sham stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that occipital \u03b1\u2010tACS is safe and enhances visuospatial and executive functions in patients with DLB. Improvements in indirect markers of cholinergic transmission and EEG changes indicate significant neurophysiological engagement. These findings justify further exploration of \u03b1\u2010tACS as a therapeutic option for DLB patients. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29969","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:01:16Z","timestamp":1723539676000},"page":"1993-2003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Alpha <scp>tACS<\/scp> Improves Cognition and Modulates Neurotransmission in Dementia with Lewy Bodies"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-6940","authenticated-orcid":false,"given":"Alberto","family":"Benussi","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical, and Health Sciences University of Trieste  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