{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:18:32Z","timestamp":1779185912243,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1NS126227"],"award-info":[{"award-number":["RO1NS126227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are more than 30 immunoglobulin G (IgG) autoantibody biomarkers of autoimmune cerebellar ataxia reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a novel IgG biomarker targeting neurobeachin, a scaffolding protein integral to synapse formation and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and laboratory\u2010based assessment was used for a novel diagnostic biomarker of autoimmune ataxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 46\u2010year\u2010old woman had ataxia onset followed by bilateral knee pain, attributable to rheumatoid arthritis. She was negative for standard neural antibodies. Her ataxia stabilized and tremor initially improved after corticosteroid treatment, but she progressed to wheelchair\u2010dependence (on methotrexate and then rituximab) over 4\u2009years, in keeping with the trajectory encountered by many with autoimmune ataxia. In contrast, her inflammatory arthritis remitted with immunotherapy. Neurobeachin\u2010IgG was unmasked in serum and cerebrospinal fluid using protein arrays and confirmed using neurobeachin\u2010specific confocal immunofluorescence and Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neurobeachin\u2010IgG is a new neural antibody biomarker of cerebellar ataxia among a growing antibody repertoire, collectively common but often individually rare. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.29991","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T20:25:30Z","timestamp":1724271930000},"page":"2271-2275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmune Neurobeachin Cerebellar Ataxia"],"prefix":"10.1002","volume":"39","author":[{"given":"Eati","family":"Basal","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine 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