{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:34Z","timestamp":1786978174305,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Glucocerebrosidase 1\n                      <jats:italic>(GBA1)<\/jats:italic>\n                      mutations are associated with reduced survival in Parkinson's disease but their effect on survival in dementia with Lewy bodies (DLB) is unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the impact of\n                      <jats:italic>GBA1<\/jats:italic>\n                      mutations on survival among Ashkenazi Jews with DLB, while controlling for\n                      <jats:italic>APOE<\/jats:italic>\n                      status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and forty participants from Tel Aviv Medical Center, Israel were genotyped for\n                      <jats:italic>GBA1<\/jats:italic>\n                      mutations and\n                      <jats:italic>APOE<\/jats:italic>\n                      polymorphisms. Survival rates and follow\u2010up cognitive screening scores were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>GBA1<\/jats:italic>\n                      mutation carriers had a two\u2010fold increased risk of death (HR\u2009=\u20091.999), while\n                      <jats:italic>APOE<\/jats:italic>\n                      status did not independently affect survival. In a subset of patients with available clinical data (N\u2009=\u200963), carriers of the\n                      <jats:italic>APOE \u03b54<\/jats:italic>\n                      allele showed faster cognitive deterioration, while\n                      <jats:italic>GBA1<\/jats:italic>\n                      mutation carriers also declined more rapidly albeit not significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding the genetic effects on survival and progression is crucial for patient counseling and inclusion in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30003","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T07:13:25Z","timestamp":1725002005000},"page":"2280-2285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of\n                    <scp>GBA1<\/scp>\n                    Mutations and\n                    <scp>APOE<\/scp>\n                    Polymorphisms on Survival and Progression Among Ashkenazi Jews with Dementia with Lewy Bodies"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-9656","authenticated-orcid":false,"given":"Tamara","family":"Shiner","sequence":"first","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv 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