{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:49:48Z","timestamp":1785498588770,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PNRR\u2010M4C2\u2010I1.3 Project PE_00000019"],"award-info":[{"award-number":["PNRR\u2010M4C2\u2010I1.3 Project PE_00000019"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral immune cells critically contribute to the clinical\u2010pathological progression of neurodegenerative diseases and also represent a reliable frame for translational applications. However, data on progressive supranuclear palsy (PSP) are almost scarce in this regard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our goal is to provide a broad biological characterization of peripheral immune cells in a selected PSP cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one PSP patients scored on the PSP Rating Scale (PSPRS), and 59 controls were enrolled. The blood cell count was collected, together with the neutrophil\u2010to\u2010lymphocyte ratio (NLR) calculation. In a subgroup of patients and controls, the peripheral blood mononuclear cells (PBMCs) were analyzed by the mitochondrial bioenergetic performance and the western blot assay of the nuclear factor erythroid 2\u2010related factor (NRF2)\/heme oxygenase 1 (HO\u20101) pathway and the total tau (t\u2010tau) and phosphorylated tau (p\u2010tau) proteins. Case\u2013control comparison and correlation analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PSP patients had a NLR higher than controls, with increased circulating neutrophils. The leukocyte metabolism was also globally increased and the NRF2\/HO\u20101 pathway activated in patients. P\u2010tau, but not t\u2010tau, significantly accumulated in PSP PBMCs and inversely correlated with the PSPRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PSP displays a systemic inflammatory shift of the peripheral immunity, which may justify a metabolic reprogramming of the blood leukocytes. Consistently, the NRF2\/HO\u20101 pathway, a master regulator of inflammatory and metabolic response, was activated. PBMCs also engulf tau proteins, especially p\u2010tau, in a way inverse to the disease severity, allowing for a peripheral tracking of tauopathy in patients. Immunometabolic targets may, therefore, gain relevance to PSP in biomarker or therapeutic purposes. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30009","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T10:15:41Z","timestamp":1726481741000},"page":"2211-2219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immunometabolic Signature and Tauopathy Markers in Blood Cells of Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"39","author":[{"given":"Marco","family":"Rosina","sequence":"first","affiliation":[{"name":"Neurology Unit Fondazione PTV \u2013 Tor Vergata University Hospital  Rome Italy"},{"name":"IRCCS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Veltri","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Nesci","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Santa Lucia  Rome Italy"},{"name":"Neurology Unit, Department of Systems Medicine Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Bissacco","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bovenzi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Mascioli","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems 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