{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:10:35Z","timestamp":1788862235187,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011707","name":"PSP Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Seed amplification assay (SAA) testing has been developed as a biomarker for the diagnosis of \u03b1\u2010synuclein\u2010related neurodegenerative disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to assess the rate of \u03b1\u2010synuclein SAA positivity in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) and to analyze clinical and pathological features of SAA\u2010positive and \u2010negative cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 96 cerebrospinal fluid samples from clinically diagnosed PSP (n\u2009=\u200959) and CBS (n\u2009=\u200937) cases were analyzed using \u03b1\u2010synuclein SAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of 59 (10.2%) PSP cases were \u03b1\u2010synuclein SAA positive, including one case who was MSA\u2010type positive. An exploratory analysis showed that PSP cases who were Parkinson's disease\u2013type positive were older and had a shorter disease duration compared with SAA\u2010negative cases. In contrast, 11 of 37 (29.7%) CBS cases were \u03b1\u2010synuclein SAA positive, including two cases who were MSA\u2010type positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that \u03b1\u2010synuclein seeds can be detected in PSP and CBS using a cerebrospinal fluid \u03b1\u2010synuclein SAA, and in PSP this may impact on clinical course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30019","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:48:23Z","timestamp":1726818503000},"page":"2285-2291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evaluation of Cerebrospinal Fluid <b>\u03b1<\/b>\u2010Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7303-6416","authenticated-orcid":false,"given":"David P.","family":"Vaughan","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riona","family":"Fumi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marte","family":"Theilmann Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Georgiades","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Lux","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Obrocki","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Amprion Inc.  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Ansorge","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieren S.J.","family":"Allinson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Cambridge University Hospitals NHS Trust and MRC Cognition and Brain Sciences Unit, University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-6995","authenticated-orcid":false,"given":"Thomas T.","family":"Warner","sequence":"additional","affiliation":[{"name":"Reta Lila Weston Institute, UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Jaunmuktane","sequence":"additional","affiliation":[{"name":"Reta Lila Weston Institute, UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjum","family":"Misbahuddin","sequence":"additional","affiliation":[{"name":"Department of Neurology Queen's Hospital  Romford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Nigel","family":"Leigh","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Brighton and Sussex Medical School  Brighton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyd C.P.","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Wessex Neurological Centre, University Hospitals Southampton NHS Foundation Trust  Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-286X","authenticated-orcid":false,"given":"Kailash P.","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Movement Disorders Centre, UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Church","sequence":"additional","affiliation":[{"name":"Department of 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