{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:58:42Z","timestamp":1788447522172,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Unilateral subthalamic nucleus (STN) ablation using magnetic resonance\u2013guided focused ultrasound (MRgFUS) is being explored as a new treatment for asymmetric Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aims were to study the efficacy and safety of this treatment in asymmetric PD patients and to characterize the lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, single\u2010center, open\u2010label study evaluated asymmetric PD patients at 6 (n\u2009=\u200920) and 12\u2009months (n\u2009=\u200912) after MRgFUS lesion of the STN. The primary outcome was the change in the Movement Disorders Society\u2010Unified Parkinson's Disease Rating Scale, Part III (MDS\u2010UPDRS III), score in\n                      <jats:italic>off<\/jats:italic>\n                      medication on the treated side and the adverse events (AEs) at 6\u2010month follow\u2010up. We also evaluated cognitive\u2013neuropsychological changes, self\u2010assessment of clinical improvement, and the correlation of the lesion volume with the motor outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On the treated side, the MDS\u2010UPDRS III score (mean difference\u2009=\u200913.8) and the scores in rigidity, bradykinesia, and tremor improved (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) throughout the follow\u2010up compared to baseline (at 6\u2009months: rigidity mean difference\u2009=\u20092.8, improvement: 83.5%; bradykinesia mean difference\u2009=\u20096.0, improvement: 69.4%; tremor mean difference\u2009=\u20094.7, improvement: 91.5%). One patient had severe weakness in the treated hemibody, 1 had moderate dyskinesia, and 1 was in moderate confusional state that became mild (weakness) or completely resolved (dyskinesia and confusional state) at 6\u2009months. The rest of the AEs were mild. We observed no clinically relevant changes in cognitive\u2013neuropsychological tests. The percentage of ablation of the STN correlated with the improvement in the total MDS\u2010UPDRS III and contralateral tremor scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Unilateral MRgFUS lesion of the STN resulted in a significant motor improvement. We observed no persistent severe AEs, although mild, mostly transient AEs were frequent. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30020","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:18:45Z","timestamp":1726712325000},"page":"2230-2241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Unilateral Magnetic Resonance\u2013Guided Focused Ultrasound Lesion of the Subthalamic Nucleus in Parkinson's Disease: A Prospective 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