{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:52:15Z","timestamp":1792900335116,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006599","name":"Focused Ultrasound Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No clinical trials have been reported on the use of focused ultrasound (FUS) for treating cervical dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to confirm the efficacy and safety of FUS pallidothalamic tractotomy for cervical dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, open\u2010label, non\u2010controlled pilot study. The primary outcome was defined as a change in the score for the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) from baseline to 6\u2009months after FUS pallidothalamic tractotomy. The secondary outcomes included a change in the neck scale for the Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale (BFMDRS), mood scales including Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Apathy Evaluating Scale (AES), and adverse events. Patients were assessed for TWSTRS, BFMDRS, and adverse events at baseline, 1\u2009week, 1\u2009month, 3\u2009months, and 6\u2009months after treatment. BDI, BAI, and AES were assessed at baseline and 6\u2009months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients were enrolled in this study. The mean age of onset of dystonia was 51.6\u2009\u00b1\u200910.2\u2009years. The TWSTRS at 6\u2009months (29.9\u2009\u00b1\u200916.0, range: 3\u201355) was significantly improved by 43.4% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) from baseline. The BFMDRS\u2010Neck scales at 6\u2009months (4.2\u2009\u00b1\u20092.8) were significantly improved by 38.2% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) from baseline. The BDI, BAI, and AES at 6\u2009months were improved by 23.2%, 10.9%, and 30.3%, respectively from baseline. Reduced hand dexterity in three patients and weight gain in two patients were confirmed at the last evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that FUS pallidothalamic tractotomy may be an effective treatment option for patients with cervical dystonia. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30030","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T03:09:38Z","timestamp":1730516978000},"page":"132-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Focused Ultrasound Pallidothalamic Tractotomy in Cervical Dystonia: A Pilot Study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-3244","authenticated-orcid":false,"given":"Shiro","family":"Horisawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohui","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of FUS Center Moriyama Neurological Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kakegawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kumagaya General Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Center Hospital of the National Center of the Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Kohara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsumi","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takakazu","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11310-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207729"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13762"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/dyst.2022.10655"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1478288"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1570-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103408"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51532"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000840"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.808810"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.2.JNS172514"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2019.00002"},{"key":"e_1_2_9_14_1","first-page":"522","volume-title":"Stereotaxy Hum Brain. Stuttgart: Georg Thieme","author":"Hassler R","year":"1982"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.4.SPINE191523"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00839204"},{"issue":"10","key":"e_1_2_9_17_1","first-page":"437","article-title":"Stereotaxic treatment of torticollis according to animal experiment experiences about direction determined movement","volume":"41","author":"Hassler R","year":"1970","journal-title":"Nervenarzt"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130509"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.2.195"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2022.1430"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51333"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.601153"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.06.055"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1961.18.4.0429"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534084"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820f2e4f"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102249"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09703-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.9.JNS191202"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11841-1"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.30030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:05:19Z","timestamp":1760951119000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.30030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/mds.30030"],"URL":"https:\/\/doi.org\/10.1002\/mds.30030","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,2]]},"assertion":[{"value":"2024-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}