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Subjects were categorized as cognitively normal (NC), mild cognitive impairment (MCI), or dementia. Global and regional standardized uptake value ratios (SUVR) were estimated in predefined <jats:italic>cognitive volumes of interest<\/jats:italic> (<jats:italic>VOI<\/jats:italic>) derived from voxel\u2010wise comparison analysis among the cognitive groups, namely the prefrontal, parietal, precentral cortices, lingual gyrus, and supplementary motor area. Generalized linear models assessed the relationship between <jats:sup>18<\/jats:sup>F\u2010florbetaben SUVRs and neuropsychological testing, adjusting for age and sex. Subgroup analysis focused on the polysomnography\u2010confirmed iRBD\u2010continuum subset (n\u2009=\u200941) encompassing phenoconverters and nonconverters in our prospective iRBD cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010six subjects were classified as follows: 14 NC, 54 MCI, and 18 dementia. The proportion of positive \u03b2\u2010amyloid scans increased with advanced cognitive stages (<jats:italic>P<\/jats:italic>\u2009=\u20090.038). \u03b2\u2010Amyloid signals in <jats:italic>cognitive VOI<\/jats:italic>s were elevated in subgroups showing impairment in Trail\u2010Making Test B (TMT\u2010B). A linear association between TMT\u2010B <jats:italic>z<\/jats:italic> score and global cortical \u03b2\u2010amyloid levels was observed in the iRBD\u2010continuum subset (<jats:italic>P<\/jats:italic>\u2009=\u20090.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cortical \u03b2\u2010amyloid accumulates with declines in executive function within the RBD\u2013LBD continuum. TMT\u2010B performance may be a useful marker associating with \u03b2\u2010amyloid load, particularly in the iRBD population. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30031","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T09:19:49Z","timestamp":1728897589000},"page":"2259-2270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive Impact of <b>\u03b2<\/b>\u2010Amyloid Load in the Rapid Eye Movement Sleep Behavior Disorder\u2013Lewy Body Disease Continuum"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-7348","authenticated-orcid":false,"given":"Kyung Ah","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Neurology, Seoul Metropolitan 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heejung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Radiation Medicine, Medical Research Center Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-9180","authenticated-orcid":false,"given":"Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7760-5524","authenticated-orcid":false,"given":"Seungmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunwoong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of 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