{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:28:57Z","timestamp":1791322137928,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The p.Ser71Arg RAB32 variant was recently associated with Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to investigate the presence of <jats:italic>RAB32<\/jats:italic> variants in a large multiethnic group of individuals affected and unaffected by PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried our proprietary database that contains exome\/genome sequencing data of &gt;180,000 individuals. Additional PD patients were genotyped, and proximal p.Ser71Arg\u2010associated haplotypes were constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>p.Ser71Arg was present in 11 PD patients (73% from northern Italy) and in 35 individuals (89% from the Middle East and North Africa [MENA]) aged &lt;50\u2009years without PD\u2010relevant symptoms. It was found <jats:italic>in\u2010cis<\/jats:italic> to a set of proximal single\u2010nucleotide polymorphisms. Additional <jats:italic>RAB32<\/jats:italic> variants were comparably frequent in PD and non\u2010PD individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The RAB32 p.Ser71Arg variant defines a cluster of PD patients in northern Italy. Globally, it is most prevalent in MENA. Our data indicate that p.Ser71Arg causes PD and that it occurred only once, through a founder event. Other <jats:italic>RAB32<\/jats:italic> variants are unlikely to cause PD. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30041","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T14:49:59Z","timestamp":1729954199000},"page":"147-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic and Epidemiological Insights into <scp><i>RAB32<\/i><\/scp>\u2010Linked Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"given":"Mandy","family":"Radefeldt","sequence":"first","affiliation":[{"name":"CENTOGENE GmbH  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Lemke","sequence":"additional","affiliation":[{"name":"CENTOGENE GmbH  Rostock 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