{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:30:58Z","timestamp":1782484258624,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["310962"],"award-info":[{"award-number":["310962"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022793","name":"Turun Yliopistos\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019391","name":"Turun yliopiston tutkijakoulu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Parkinson's disease (PD), postural instability and gait disorder (PIGD) symptoms are associated with a worse prognosis for an unknown reason.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to explore the relationship between cannabinoid receptor type 1 (CB1R) availability and motor symptoms in PD with [<jats:sup>18<\/jats:sup>F]FMPEP\u2010<jats:italic>d<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> positron emission tomography (PET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen individuals with PD underwent [<jats:sup>18<\/jats:sup>F]FMPEP\u2010<jats:italic>d<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> PET to measure cerebral CB1R availability. The Unified Parkinson's Disease Rating Scale motor part (UPDRS\u2010III) was used to evaluate the motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A negative correlation was observed between [<jats:sup>18<\/jats:sup>F]FMPEP\u2010<jats:italic>d<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> <jats:italic>V<\/jats:italic><jats:sub>T<\/jats:sub> and PIGD score (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) as well as rigidity subscore (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Both clusters covered widespread areas of both hemispheres. In contrast, tremor or bradykinesia did not correlate to [<jats:sup>18<\/jats:sup>F]FMPEP\u2010<jats:italic>d<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> <jats:italic>V<\/jats:italic><jats:sub>T<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gait, postural instability, and rigidity in PD are associated with decreased CB1R availability, unlike tremor or bradykinesia, suggesting that the endocannabinoid system has a role in the pathophysiology of different motor symptoms in PD. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30042","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T05:35:09Z","timestamp":1729575309000},"page":"163-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired Gait, Postural Instability, and Rigidity in Relation to <scp>CB1<\/scp> Receptor Availability in Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-7516","authenticated-orcid":false,"given":"Riikka","family":"Ajalin","sequence":"first","affiliation":[{"name":"Turku PET Centre Turku University and Turku University Hospital  Turku Finland"},{"name":"Neurocenter, Turku University Hospital and Clinical Neurosciences University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidar","family":"Al\u2010Abdulrasul","sequence":"additional","affiliation":[{"name":"Turku 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