{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:48Z","timestamp":1786978188672,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008358","name":"Hersenstichting","doi-asserted-by":"publisher","award":["DR\u20102019\u201000313"],"award-info":[{"award-number":["DR\u20102019\u201000313"]}],"id":[{"id":"10.13039\/501100008358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The cerebellar cognitive affective syndrome (CCAS) encompasses cognitive and affective symptoms in patients with cerebellar disorders, for which no proven treatment is available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our primary objective was to study the effect of cerebellar anodal transcranial direct current stimulation (tDCS) on cognitive performance in CCAS patients. Secondary effects on ataxia severity, mood, and quality of life were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a randomized, double\u2010blind, sham\u2010controlled trial. Thirty\u2010five patients with CCAS were included and received 10 sessions of 20\u2009minutes sham (n\u2009=\u200917) or real (n\u2009=\u200918) tDCS, with a current of 2\u2009mA. Cognitive performance was assessed using executive function subtests of the computerized Test of Attentional Performance (TAP), with the composite as primary endpoint. Secondary outcomes were ataxia severity, mood, and quality of life. Outcomes were evaluated 1, 3, 6, and 12 months post\u2010intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cerebellar tDCS was well tolerated and no serious adverse events related to the intervention occurred. No significant tDCS effect was found on cognitive performance. Improvement on the TAP was observed in the sham group 1\u2009month post\u2010treatment (estimate\u2009=\u2009\u22120.248, 95% CI,\u2009\u22120.49 to \u22120.01), but not clinically relevant. A positive tDCS effect was observed for ataxia severity 1\u2009month post\u2010treatment (estimate\u2009=\u2009\u22120.985, 95% CI,\u2009\u22121.94 to \u22120.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Ten sessions of 20\u2009minutes cerebellar anodal tDCS did not prove efficacious for CCAS\u2010related cognitive impairment, but a significant positive effect of tDCS was found for ataxia severity, aligning with previous findings indicative of tDCS as a therapeutic neuromodulation tool in cerebellar disorders. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30043","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T03:19:57Z","timestamp":1730517597000},"page":"121-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebellar Transcranial Direct Current Stimulation in the Cerebellar Cognitive Affective Syndrome: A Randomized, Double\u2010Blind, Sham\u2010Controlled Trial"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0767-9063","authenticated-orcid":false,"given":"Stacha F.I.","family":"Reumers","sequence":"first","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-1287","authenticated-orcid":false,"given":"Roderick P.P.W.M.","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.L.G.","family":"Schutter","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology Helmholtz Institute, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Teerenstra","sequence":"additional","affiliation":[{"name":"IQ Health Science Department, Biostatistics Section Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy P.C.","family":"Kessels","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour Radboud University  Nijmegen The Netherlands"},{"name":"Department of Medical 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